Health effects of phloretin: from chemistry to medicine

被引：86
作者：
Behzad, Sahar [1 ]
Sureda, Antoni [2 ]
Barreca, Davide [3 ]
Nabavi, Seyed Fazel [4 ]
Rastrelli, Luca [5 ]
Nabavi, Seyed Mohammad [4 ]
机构：
[1] Shahid Beheshti Univ Med Sci, Sch Pharm, Dept Pharmacognosy, Tehran, Iran
[2] Univ Balearic Isl, Grp Nutr Comunitaria & Estres Oxidatiu, CIBEROBN Physiopathol Obes & Nutr, Palma De Mallorca, Illes Balears, Spain
[3] Univ Messina, Dipartimento Sci Chim Biol Farmaceut & Ambientali, Viale F Stagno dAlcontres 31, I-98166 Messina, Italy
[4] Baqiyatallah Univ Med Sci, Appl Biotechnol Res Ctr, POB 19395-5487, Tehran, Iran
[5] Univ Salerno, Dipartimento Farm, Via Giovanni Paolo II, I-84084 Fisciano, Italy
来源：
PHYTOCHEMISTRY REVIEWS | 2017年 / 16卷 / 03期
关键词：
Anticancer; Dihydrochalcones; Phenolic compound; Phloretin; ANTIOXIDANT ACTIVITY; ADIPOCYTE DIFFERENTIATION; OXIDATIVE STRESS; FLAVONOIDS; CELLS; APPLE; DIHYDROCHALCONES; APOPTOSIS; PHLORHIZIN; BIOAVAILABILITY;
D O I：
10.1007/s11101-017-9500-x
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Dihydrochalcones are a class of secondary metabolites, whose demand in biological and pharmacological applications is rapidly growing. Phloretin is one of the best known and abundant dihydrochalcone characterized by the presence of 2,6-dihydroxyacetophenone pharmacophore. It is a versatile molecule with anticancer, antiosteoclastogenic, antifungal, antiviral, anti-inflammatory, antibacterial and estrogenic activities and able to increase the fluidity of biological membranes and penetration of administered drugs. In this review we have performed a critical evaluation of available literature as far as phloretin beneficial effects and activation/block of intracellular signal cascade are of concern. In addition, we supply useful information on its chemical properties, sources and bioavailability.
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收藏
页码：527 / 533
页数：7
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