Intranuclear neuronal inclusions: A common pathogenic mechanism for glutamine-repeat neurodegenerative diseases?

被引:323
作者
Ross, CA [1 ]
机构
[1] Johns Hopkins Univ, Sch Med, Dept Psychiat, Div Neurobiol,Lab Mol Neurobiol, Baltimore, MD 21205 USA
[2] Johns Hopkins Univ, Sch Med, Dept Neurosci, Div Neurobiol,Lab Mol Neurobiol, Baltimore, MD 21205 USA
关键词
D O I
10.1016/S0896-6273(00)80405-5
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
[No abstract available]
引用
收藏
页码:1147 / 1150
页数:4
相关论文
共 15 条
[1]   Rethinking genotype and phenotype correlations in polyglutamine expansion disorders [J].
Andrew, SE ;
Goldberg, YP ;
Hayden, MR .
HUMAN MOLECULAR GENETICS, 1997, 6 (12) :2005-2010
[2]  
BECHER MW, 1997, IN PRESS NEUROBIOL D, V4
[3]   Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rad guanine nucleotide exchange factor domain [J].
Colomer, V ;
Engelender, S ;
Sharp, AH ;
Duan, K ;
Cooper, JK ;
Lanahan, A ;
Lyford, G ;
Worley, P ;
Ross, CA .
HUMAN MOLECULAR GENETICS, 1997, 6 (09) :1519-1525
[4]   Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation [J].
Davies, SW ;
Turmaine, M ;
Cozens, BA ;
DiFiglia, M ;
Sharp, AH ;
Ross, CA ;
Scherzinger, E ;
Wanker, EE ;
Mangiarini, L ;
Bates, GP .
CELL, 1997, 90 (03) :537-548
[5]   Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain [J].
DiFiglia, M ;
Sapp, E ;
Chase, KO ;
Davies, SW ;
Bates, GP ;
Vonsattel, JP ;
Aronin, N .
SCIENCE, 1997, 277 (5334) :1990-1993
[6]   Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract [J].
Goldberg, YP ;
Nicholson, DW ;
Rasper, DM ;
Kalchman, MA ;
Koide, HB ;
Graham, RK ;
Bromm, M ;
KazemiEsfarjani, P ;
Thornberry, NA ;
Vaillancourt, JP ;
Hayden, MR .
NATURE GENETICS, 1996, 13 (04) :442-449
[7]   The genetic defect causing Huntington's disease: Repeated in other contexts? [J].
Gusella, JF ;
Persichetti, F ;
MacDonald, ME .
MOLECULAR MEDICINE, 1997, 3 (04) :238-246
[8]   The cerebellar leucine-rich acidic nuclear protein interacts with ataxin-1 [J].
Matilla, A ;
Koshy, BT ;
Cummings, C ;
Isobe, T ;
Orr, HT ;
Zoghbi, HY .
NATURE, 1997, 389 (6654) :974-978
[9]   Oligomerization of expanded-polyglutamine domain fluorescent fusion proteins in cultured mammalian cells [J].
Onodera, O ;
Burke, JR ;
Miller, SE ;
Hester, S ;
Tsuji, S ;
Roses, AD ;
Strittmatter, WJ .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 238 (02) :599-605
[10]   Ectopically expressed CAG repeats cause intranuclear inclusions and a progressive late onset neurological phenotype in the mouse [J].
Ordway, JM ;
TallaksenGreene, S ;
Gutekunst, CA ;
Bernstein, EM ;
Cearley, JA ;
Wiener, HW ;
Dure, LS ;
Lindsey, R ;
Hersch, SM ;
Jope, RS ;
Albin, RL ;
Detloff, PJ .
CELL, 1997, 91 (06) :753-763