共 65 条
Virus-like particles and capsomeres are potent vaccines against cutaneous alpha HPVs
被引:22
作者:

Senger, Tilo
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机构:
German Canc Res Ctr, Dept Genome Modificat & Carcinogenesis, D-69120 Heidelberg, Germany German Canc Res Ctr, Dept Genome Modificat & Carcinogenesis, D-69120 Heidelberg, Germany

Schaedlich, Lysann
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机构:
German Canc Res Ctr, Dept Genome Modificat & Carcinogenesis, D-69120 Heidelberg, Germany German Canc Res Ctr, Dept Genome Modificat & Carcinogenesis, D-69120 Heidelberg, Germany

Textor, Sonja
论文数: 0 引用数: 0
h-index: 0
机构:
German Canc Res Ctr, Dept Genome Modificat & Carcinogenesis, D-69120 Heidelberg, Germany German Canc Res Ctr, Dept Genome Modificat & Carcinogenesis, D-69120 Heidelberg, Germany

Klein, Corinna
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机构:
German Canc Res Ctr, Dept Genome Modificat & Carcinogenesis, D-69120 Heidelberg, Germany German Canc Res Ctr, Dept Genome Modificat & Carcinogenesis, D-69120 Heidelberg, Germany

Michael, Kristina M.
论文数: 0 引用数: 0
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机构:
German Canc Res Ctr, Dept Genome Modificat & Carcinogenesis, D-69120 Heidelberg, Germany German Canc Res Ctr, Dept Genome Modificat & Carcinogenesis, D-69120 Heidelberg, Germany

Buck, Christopher B.
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, Cellular Oncol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA German Canc Res Ctr, Dept Genome Modificat & Carcinogenesis, D-69120 Heidelberg, Germany

Gissmann, Lutz
论文数: 0 引用数: 0
h-index: 0
机构:
German Canc Res Ctr, Dept Genome Modificat & Carcinogenesis, D-69120 Heidelberg, Germany German Canc Res Ctr, Dept Genome Modificat & Carcinogenesis, D-69120 Heidelberg, Germany
机构:
[1] German Canc Res Ctr, Dept Genome Modificat & Carcinogenesis, D-69120 Heidelberg, Germany
[2] NCI, Cellular Oncol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA
来源:
关键词:
Papillomavirus;
Cutaneous;
Virus-like particle;
Capsomeres;
Immunogenicity;
Prophylactic vaccine;
HUMAN-PAPILLOMAVIRUS TYPE-16;
MAJOR CAPSID PROTEIN;
NEUTRALIZING ANTIBODIES;
MONOCLONAL-ANTIBODIES;
SUSTAINED EFFICACY;
L1;
CAPSOMERES;
YOUNG-WOMEN;
EXPRESSION;
INFECTION;
INDUCE;
D O I:
10.1016/j.vaccine.2009.11.048
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
The potential as prophylactic vaccines of L1-based particles from cutaneous genus alpha human papillomavirus (HPV) types has not been assessed so far. However, there is a high medical need for such vaccines since HPV-induced skin warts represent a major burden for children and for immunocompromised adults, such as organ transplant recipients. In this study, we have examined the immunogenicity of capsomeres and virus-like particles (VLPs) from HPV types 2, 27, and 57, the most frequent causative agents of skin warts. Immunization of mice induced immune responses resembling those observed upon vaccination with HPV 16 L1-based antigens. The antibody responses were cross-reactive but type-restricted in their neutralizing capacities. Application of adjuvant led to an enhanced potential to neutralize the respective immunogen type but did not improve cross-neutralization. Vaccination with capsomeres and VLPs from all four analyzed HPV types induced robust IFN gamma-associated T-cell activation. Immunization with mixed VLPs from HPV types 2, 27, and 57 triggered an antibody response similar to that after single-type immunization and capable of efficiently neutralizing all three types. Our results imply that vaccination with combinations of VLPs from cutaneous HPV types constitutes a promising strategy to prevent HPV-induced skin lesions. (C) 2009 Elsevier Ltd. All rights reserved.
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页码:1583 / 1593
页数:11
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机构: PENN STATE UNIV, MILTON S HERSHEY MED CTR, DEPT IMMUNOL & MICROBIOL, HERSHEY, PA 17033 USA

KREIDER, JW
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机构: PENN STATE UNIV, MILTON S HERSHEY MED CTR, DEPT IMMUNOL & MICROBIOL, HERSHEY, PA 17033 USA
[10]
Identification of two cross-neutralizing linear epitopes within the L1 major capsid protein of human papillomaviruses
[J].
Combita, AL
;
Touzé, A
;
Bousarghin, L
;
Christensen, ND
;
Coursaget, P
.
JOURNAL OF VIROLOGY,
2002, 76 (13)
:6480-6486

Combita, AL
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机构: Fac Sci Pharmaceut Philippe Maupas, Mol Virol Lab, INSERM EMIU 00 10, F-37200 Tours, France

Touzé, A
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机构: Fac Sci Pharmaceut Philippe Maupas, Mol Virol Lab, INSERM EMIU 00 10, F-37200 Tours, France

Bousarghin, L
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机构: Fac Sci Pharmaceut Philippe Maupas, Mol Virol Lab, INSERM EMIU 00 10, F-37200 Tours, France

Christensen, ND
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h-index: 0
机构: Fac Sci Pharmaceut Philippe Maupas, Mol Virol Lab, INSERM EMIU 00 10, F-37200 Tours, France

Coursaget, P
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机构: Fac Sci Pharmaceut Philippe Maupas, Mol Virol Lab, INSERM EMIU 00 10, F-37200 Tours, France