Determination of the unmetabolised 18F-FDG fraction by using an extension of simplified kinetic analysis method: clinical evaluation in paragangliomas

被引:9
作者
Barbolosi, Dominique [1 ]
Hapdey, Sebastien [2 ,3 ,4 ]
Battini, Stephanie [1 ]
Faivre, Christian [1 ]
Mancini, Julien [5 ,6 ]
Pacak, Karel [7 ]
Farman-Ara, Bardia [8 ]
Taieb, David [8 ]
机构
[1] Aix Marseille Univ, Dept Pharmacokinet, UMR INSERM CRO2 911, SMARTc,Fac Med Pharm, 27 Blvd Jean Moulin, F-13385 Marseille 5, France
[2] Ctr Henri Becquerel, Dept Nucl Med, F-76038 Rouen, France
[3] Rouen Univ Hosp, Rouen, France
[4] Univ Rouen, QuantIF LITIS, EA 4108, 1 Rue Amiens, F-76038 Rouen, France
[5] Aix Marseille Univ, Econ & Social Hlth & Med Informat Proc SESSTIM, INSERM, UMR912,IRD, F-13273 Marseille, France
[6] La Timone Univ Hosp, Dept Publ Hlth, APHM, 264 Rue St Pierre, F-13385 Marseille 5, France
[7] Eunice Kennedy Shriver NICHD, Program Reprod & Adult Endocrinol, NIH, CRC, Bldg 10,Room 1E-3140,10 Ctr Dr MSC 1109, Bethesda, MD 20892 USA
[8] Aix Marseille Univ, Dept Nucl Med, La Timone Univ Hosp, European Ctr Res Med Imaging CERIMED, 264 Rue St Pierre, F-13385 Marseille 5, France
关键词
Paraganglioma; Radionuclide imaging; Positron emission tomography; Mathematical modelling; POSITRON-EMISSION-TOMOGRAPHY; PHEOCHROMOCYTOMA; PET; TUMOR; SDHB; SUV; FDG; VHL;
D O I
10.1007/s11517-015-1318-3
中图分类号
TP39 [计算机的应用];
学科分类号
081203 ; 0835 ;
摘要
Tumours with high F-18-FDG uptake values on static late PET images do not always exhibit high proliferation indices. These discrepancies might be related to high proportion of unmetabolised F-18-FDG components in the tissues. We propose a method that enables to calculate different F-18-FDG kinetic parameters based on a new mathematical approach that integrates a measurement error model. Six patients with diagnosed non-metastatic paragangliomas (PGLs) and six control patients with different types of lesions were investigated in this pilot study using F-18-FDG PET/CT. In all cases, a whole-body acquisition was followed by four static acquisitions centred over the target lesions, associated with venous blood samplings. We used an extension of the Hunter's method to calculate the net influx rate constant (K (H)). The exact net influx rate constant and vascular volume fraction (K (i) and V, respectively) were subsequently obtained by the method of least squares. Next, we calculated the mean percentages of metabolised (PM) and unmetabolised (PUM) F-18-FDG components, and the times required to reach 80 % of the amount of metabolised F-18-FDG (T80%). A test-retest evaluation indicated that the repeatability of our approach was accurate; the coefficients of variation were below 2 % regardless of the kinetic parameters considered. We observed that the PGLs were characterised by high dispersions of the maximum standardised uptake value SUVmax (9.7 +/- A 11, coefficient of variation CV = 114 %), K (i) (0.0137 +/- A 0.0119, CV = 87 %), and V (0.292 +/- A 0.306, CV = 105 %) values. The PGLs were associated with higher PUM (p = 0.02) and T80% (p = 0.02) values and lower k (3) (p = 0.02) values compared to the malignant lesions despite the similar SUVmax values (p = 0.55). The estimations of these new kinetic parameters are more accurate than SUVmax or K (i) for in vivo metabolic assessment of PGLs at the molecular level.
引用
收藏
页码:103 / 111
页数:9
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