Influence of gel and powdered formulations of coenzyme Q10 on metabolic parameters in rats

被引：4

作者：

Preuss, Harry G. ^{[1
,2
,3
]}

Echard, Bobby ^{[1
,2
,3
]}

Bagchi, Debasis ^{[4
]}

Clouatre, Dallas ^{[5
]}

Perricone, Nicholas V. ^{[6
]}

机构：

[1] Georgetown Univ, Dept Physiol, Med Ctr, Washington, DC 20057 USA

[2] Georgetown Univ, Dept Med, Med Ctr, Washington, DC 20057 USA

[3] Georgetown Univ, Dept Pathol, Med Ctr, Washington, DC 20057 USA

[4] Univ Houston, Dept Pharmacol & Pharmaceut Serv, Houston, TX 77204 USA

[5] Glykon Technol Grp LLC, Las Vegas, NV 89117 USA

[6] Michigan State Univ, Coll Human Med, E Lansing, MI 48824 USA

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 2010年 / 340卷 / 1-2期

关键词：

Coenzyme Q10; gel and powdered formulations; systolic blood pressure; DNA fragmentation; antioxidant effects; RELATIVE BIOAVAILABILITY; DISEASE; Q(10);

D O I：

10.1007/s11010-010-0414-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The healthful benefits of two commercially available formulations of coenzyme Q10 (Co Q10), one in gel and the other in a powdered form, on a variety of metabolic parameters in Sprague-Dawley rats (SD) were compared to control. The principal metabolic parameters examined were systolic blood pressure (SBP), DNA fragmentation, and free radical formation in hepatic and renal tissues. Compared to control, the powdered formulation significantly decreased SBP in the normotensive SD, whereas both commercial formulations lowered hepatic and renal DNA fragmentation and free radical formation. The gel-formulation lowered hepatic DNA fragmentation more than the powdered-formulation. In conclusion, both gel- and powdered-formulations of Co Q10 significantly influenced the metabolic parameters assessed in a favorable fashion, with the powdered-formulation more effective on SBP and the gel-formulation more effective on overcoming hepatic DNA fragmentation. From the data, we conclude that the choice of the formulation containing Co Q10 to be used should be based on the desired healthful benefits.

引用

页码：169 / 173

页数：5

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