MicroRNA miR-92a-3p regulates breast cancer cell proliferation and metastasis via regulating B-cell translocation gene 2 (BTG2)

被引：32
|
作者：
Jinghua, Huang [1 ]
Qinghua, Zhou [2 ]
Chenchen, Chen [3 ]
Lili, Chen [4 ]
Xiao, Xu [3 ]
Yunfei, Wang [3 ]
Zhengzhe, An [1 ]
Changxiu, Lin [5 ]
Hui, Han [3 ]
机构：
[1] Yanbian Univ, Dept Radiat Oncol, Affiliated Hosp, Yanbian, Jilin, Peoples R China
[2] Zoucheng Peoples Hosp, Dept Pain Control, Jining, Shandong, Peoples R China
[3] Jining Med Univ, Affiliated Hosp, Dept Gynecol, Jining, Shandong, Peoples R China
[4] Huaiyin Peoples Hosp, Dept Anesthesiol, Jinan, Shandong, Peoples R China
[5] Yanbian Univ, Affiliated Hosp, Cent Lab, Yanbian, Jilin, Peoples R China
来源：
BIOENGINEERED | 2021年 / 12卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Breast cancer; miR-92a-3p; BTG2;
D O I：
10.1080/21655979.2021.1924543
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
MicroRNAs (miRNAs) dysregulation contributes to tumorigenesis, and it is reported that abnormal miR-92a-3p expression participates in multiple cancers' occurrence and progression. This study focuses on miR-92a-3p's functions and regulatory mechanism in breast cancer (BC). The current study proved miR-92a-3p expression was enhanced in BC tissues and cells, and its high expression was related to increased TNM stage and larger tumor size of BC patients. Functionally, transfection of miR-92a-3p mimics facilitated BC cell proliferation and metastasis, yet transfection of miR-92a-3p inhibitors functioned oppositely. In addition, BTG2 was verified as a direct miR-92a-3p target in BC cells. This research indicated that miR-92a-3p facilitates BC cell proliferation and metastasis through repressing BTG2 expression.
引用
收藏
页码：2033 / 2044
页数：12
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