HTLV type I tax oncoprotein binds to DNA topoisomerase I and inhibits its catalytic activity

被引：9

作者：

Yoshida, M ^{[1
]}

Suzuki, T ^{[1
]}

机构：

[1] Univ Tokyo, Inst Med Sci, Dept Cellular & Mol Biol, Tokyo, Japan

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2000年 / 16卷 / 16期

关键词：

D O I：

10.1089/08892220050193083

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

HTLV-1 Tax oncoprotein exerts pleiotropic effects on cellular regulatory systems, trans-activation and trans-repression of transcription and promotion of the cell cycle, through interaction with various cellular factors. Here, we report Tax-mediated inhibition of DNA topoisomerase I. The interaction of Tax with topoisomerase I was demonstrated in vitro and also in vivo, and inhibition of DNA relaxation activity of topoisomerase I was clearly shown. These results suggested that Tax has a novel potential to affect various cellular processes, such as transcription and maintenance of genomic stability, in which DNA topoisomerase I is involved.

引用

页码：1639 / 1645

页数：7

共 44 条

[1] Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300 [J].

Bex, F ;

Yin, MJ ;

Burny, A ;

Gaynor, RB .

MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (04) :2392-2405

[2] Mitotic chromosome condensation in the rDNA requires TRF4 and DNA topoisomerase I in Saccharomyces cerevisiae [J].

Castano, IB ;

Brzoska, PM ;

Sadoff, BU ;

Chen, HY ;

Christman, MF .

GENES & DEVELOPMENT, 1996, 10 (20) :2564-2576

[3] DNA TOPOISOMERASES - ESSENTIAL ENZYMES AND LETHAL TARGETS [J].

CHEN, AY ;

LIU, LF .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1994, 34 :191-218

[4] INTERACTION OF HTLV-1 TAX1 WITH P67(SRF) CAUSES THE ABERRANT INDUCTION OF CELLULAR IMMEDIATE EARLY GENES THROUGH CARG BOXES [J].

FUJII, M ;

TSUCHIYA, H ;

CHUHJO, T ;

AKIZAWA, T ;

SEIKI, M .

GENES & DEVELOPMENT, 1992, 6 (11) :2066-2076

[5] FUNCTIONAL ACTIVATION OF THE LONG TERMINAL REPEAT OF HUMAN T-CELL LEUKEMIA-VIRUS TYPE-I BY A TRANS-ACTING FACTOR [J].

FUJISAWA, J ;

SEIKI, M ;

KIYOKAWA, T ;

YOSHIDA, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (08) :2277-2281

[6] Modulation of DNA topoisomerase I activity by p53 [J].

Gobert, C ;

Bracco, L ;

Rossi, F ;

Olivier, M ;

Tazi, J ;

Lavelle, F ;

Larsen, AK ;

Riou, JF .

BIOCHEMISTRY, 1996, 35 (18) :5778-5786

[7] ROLE OF HUMAN T-CELL LEUKEMIA-VIRUS TYPE-1 X-REGION PROTEINS IN IMMORTALIZATION OF PRIMARY HUMAN-LYMPHOCYTES IN CULTURE [J].

GRASSMANN, R ;

BERCHTOLD, S ;

RADANT, I ;

ALT, M ;

FLECKENSTEIN, B ;

SODROSKI, JG ;

HASELTINE, WA ;

RAMSTEDT, U .

JOURNAL OF VIROLOGY, 1992, 66 (07) :4570-4575

[8] DEVELOPMENT OF LEUKEMIA IN MICE TRANSGENIC FOR THE TAX GENE OF HUMAN T-CELL LEUKEMIA-VIRUS TYPE-I [J].

GROSSMAN, WJ ;

KIMATA, JT ;

WONG, FH ;

ZUTTER, M ;

LEY, TJ ;

RATNER, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (04) :1057-1061

[9]

HINO S, 1985, JPN J CANCER RES, V76, P474

[10] TAX PROTEIN OF HUMAN T-CELL LEUKEMIA-VIRUS TYPE-I BINDS TO THE ANKYRIN MOTIFS OF INHIBITORY FACTOR KAPPA-B AND INDUCES NUCLEAR TRANSLOCATION OF TRANSCRIPTION FACTOR NF-KAPPA-B PROTEINS FOR TRANSCRIPTIONAL ACTIVATION [J].

HIRAI, H ;

SUZUKI, T ;

FUJISAWA, J ;

INOUE, J ;

YOSHIDA, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (09) :3584-3588

← 1 2 3 4 5 →