A-1438-G serotonin receptor type 2A (5-HTR2A) gene polymorphism in patients with schizophrenia

被引：0
作者：
Mityushina, NG [1 ]
Abramova, LI [1 ]
Kaleda, VG [1 ]
Golimbet, VE [1 ]
机构：
[1] Russian Acad Med Sci, Mental Hlth Res Ctr, Moscow 109801, Russia
来源：
ZHURNAL NEVROPATOLOGII I PSIKHIATRII IMENI S S KORSAKOVA | 2003年 / 103卷 / 03期
关键词：
schizophrenia; serotonin; A-1438-G 5-HTR2A gene polymorphism;
D O I：
暂无
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
A-1438-G 5-HTR2A gene polymorphism is known to be related to some clinical presentations of endogenous psychoses, in particular, of schizophrenia. The present study aim was to study association between clinical appearances of schizophrenia and A-1438-G allelic polymorphism. Alleles (A and G) and genotypes (AA, AG and GG) distribution did not significantly differ between patients and control groups. No association has been found between the genotypes and clinical characteristics of the patients, such as age at disease onset, age at psychosis manifestation, as well as positive, negative and general psychopathological symptoms severity measured by PANSS.
引用
收藏
页码：43 / 46
页数：4
相关论文
共 36 条
[21]   No evidence for association of serotonin-2A receptor variant (102T/C) with schizophrenia or clozapine response in a Chinese population [J].
Lin, CH ;
Tsai, SJ ;
Yu, YWY ;
Song, HL ;
Tu, PC ;
Sim, CB ;
Hsu, CP ;
Yang, KH ;
Hong, CJ .
NEUROREPORT, 1999, 10 (01) :57-60
[22]  
Mann JJ, 1997, AM J PSYCHIAT, V154, P1451
[23]   Aggression and anger-related traits associated with a polymorphism of the tryptophan hydroxylase gene [J].
Manuck, SB ;
Flory, JD ;
Ferrell, RE ;
Dent, KM ;
Mann, JJ ;
Muldoon, MF .
BIOLOGICAL PSYCHIATRY, 1999, 45 (05) :603-614
[24]  
MOSOLOV SN, 2001, SHKALY PSIKHOMETRICH
[25]   Association of a polymorphism of the 5HT2A receptor gene promoter region with alcohol dependence [J].
Nakamura, T ;
Matsushita, S ;
Nishiguchi, N ;
Kimura, M ;
Yoshino, A ;
Higuchi, S .
MOLECULAR PSYCHIATRY, 1999, 4 (01) :85-88
[26]   Association between 5HT2A receptor gene promoter region polymorphism and eating disorders in Japanese patients [J].
Nishiguchi, N ;
Matsushita, S ;
Suzuki, K ;
Murayama, M ;
Shirakawa, O ;
Higuchi, S .
BIOLOGICAL PSYCHIATRY, 2001, 50 (02) :123-128
[27]   Schizophrenia and the serotonin-2A receptor promoter polymorphism [J].
Ohara, K ;
Nagai, M ;
Tani, K ;
Tsukamoto, T ;
Ohara, K .
PSYCHIATRY RESEARCH, 1999, 85 (02) :221-224
[28]   Analysis of the 5'-flanking promoter region of the 5-HT2A receptor gene in schizophrenia [J].
Ohara, K ;
Ino, A ;
Ishigaki, T ;
Tani, K ;
Tsukamoto, T ;
Nakamura, Y ;
Ohara, K .
NEUROPSYCHOPHARMACOLOGY, 1997, 17 (04) :274-278
[29]   THE ROLE OF 5-HT2A RECEPTORS IN ANTIPSYCHOTIC ACTIVITY [J].
SCHMIDT, CJ ;
SORENSEN, SM ;
KEHNE, JH ;
CARR, AA ;
PALFREYMAN, MG .
LIFE SCIENCES, 1995, 56 (25) :2209-2222
[30]   Association between the serotonin 2A receptor gene and tardive dyskinesia in chronic schizophrenia [J].
Segman, RH ;
Heresco-Levy, U ;
Finkel, B ;
Goltser, T ;
Shalem, R ;
Schlafman, M ;
Dorevitch, A ;
Yakir, A ;
Greenberg, D ;
Lerner, A ;
Lerer, B .
MOLECULAR PSYCHIATRY, 2001, 6 (02) :225-229
1234