A-1438-G serotonin receptor type 2A (5-HTR2A) gene polymorphism in patients with schizophrenia

被引：0

作者：

Mityushina, NG ^{[1
]}

Abramova, LI ^{[1
]}

Kaleda, VG ^{[1
]}

Golimbet, VE ^{[1
]}

机构：

[1] Russian Acad Med Sci, Mental Hlth Res Ctr, Moscow 109801, Russia

来源：

ZHURNAL NEVROPATOLOGII I PSIKHIATRII IMENI S S KORSAKOVA | 2003年 / 103卷 / 03期

关键词：

schizophrenia; serotonin; A-1438-G 5-HTR2A gene polymorphism;

D O I：

暂无

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A-1438-G 5-HTR2A gene polymorphism is known to be related to some clinical presentations of endogenous psychoses, in particular, of schizophrenia. The present study aim was to study association between clinical appearances of schizophrenia and A-1438-G allelic polymorphism. Alleles (A and G) and genotypes (AA, AG and GG) distribution did not significantly differ between patients and control groups. No association has been found between the genotypes and clinical characteristics of the patients, such as age at disease onset, age at psychosis manifestation, as well as positive, negative and general psychopathological symptoms severity measured by PANSS.

引用

页码：43 / 46

页数：4

共 36 条

[1] 5-HT2A receptor and bipolar affective disorder: Association studies in affected patients [J].

Arranz, MJ ;

Erdmann, J ;

Kirov, G ;

Rietschel, M ;

Sodhi, M ;

Albus, M ;

Ball, D ;

Maier, W ;

Davies, N ;

Franzek, E ;

Abusaad, I ;

Weigelt, B ;

Murray, R ;

ShimronAbarbanell, D ;

Kerwin, R ;

Propping, P ;

Sham, P ;

Nothen, MM ;

Collier, DA .

NEUROSCIENCE LETTERS, 1997, 224 (02) :95-98

[2] Meta-analysis of studies on genetic variation in 5-HT2A receptors and clozapine response [J].

Arranz, MJ ;

Munro, J ;

Sham, P ;

Kirov, G ;

Murray, RM ;

Collier, DA ;

Kerwin, RS .

SCHIZOPHRENIA RESEARCH, 1998, 32 (02) :93-99

[3]

BEREZIN FB, 1976, METODIKA MNOGOSTORON

[4] Lack of allelic association between 102T/C polymorphism of serotonin receptor type 2A gene and schizophrenia in Chinese [J].

Chen, CH ;

Lee, YR ;

Wei, FC ;

Koong, FJ ;

Hwu, HG ;

Hsiao, KJ .

PSYCHIATRIC GENETICS, 1997, 7 (01) :35-38

[5]

Du L, 1998, AM J MED GENET, V81, P522

[6] Association between seasonal affective disorder and the 5-HT2A promoter polymorphism, -1438G/A [J].

Enoch, MA ;

Goldman, D ;

Barnett, R ;

Sher, L ;

Mazzanti, CM ;

Rosenthal, NE .

MOLECULAR PSYCHIATRY, 1999, 4 (01) :89-92

[7] Systematic screening for mutations in the human serotonin-2A (5-HT2A) receptor gene: Identification of two naturally occurring receptor variants and association analysis in schizophrenia [J].

Erdmann, J ;

ShimronAbarbanell, D ;

Rietschel, M ;

Albus, M ;

Maier, W ;

Korner, J ;

Bondy, B ;

Chen, K ;

Shih, JC ;

Knapp, M ;

Propping, P ;

Nothen, MM .

HUMAN GENETICS, 1996, 97 (05) :614-619

[8] Association of short alleles of a VNTR of the serotonin transporter gene with anxiety symptoms in patients presenting after deliberate self harm [J].

Evans, J ;

Battersby, S ;

Ogilvie, AD ;

Smith, CAD ;

Harmar, AJ ;

Nutt, DJ ;

Goodwin, GM .

NEUROPHARMACOLOGY, 1997, 36 (4-5) :439-443

[9]

Galeeva AR, 2002, ZH NEVROPATOL PSIKH, V102, P53

[10]

Golimbet VE, 2000, ZH NEVROPATOL PSIKH, V100, P36

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