Pharmacology, Physiology and Genetics of the Neuropeptide S System

被引：10

作者：

Reinscheid, Rainer K. ^{[1
,2
]}

Ruzza, Chiara ^{[3
]}

机构：

[1] Friedrich Schiller Univ, Univ Hosp Jena, Inst Pharmacol & Toxicol, D-07747 Jena, Germany

[2] Westfalische Wilhelms Univ, Univ Hosp Munster, Inst Physiol 1, D-48149 Munster, Germany

[3] Univ Ferrara, Dept Neurosci & Rehabil & Lab Technol Adv Therapi, I-44121 Ferrara, Italy

来源：

PHARMACEUTICALS | 2021年 / 14卷 / 05期

关键词：

transmitter; GPCR; brainstem; anxiety; memory; genetic variation; PROTEIN-COUPLED RECEPTOR; COCAINE-SEEKING BEHAVIOR; MESSENGER-RNA LEVELS; ASTHMA SUSCEPTIBILITY; NPS RECEPTOR; BIOLOGICAL-ACTIVITY; LOCOMOTOR-ACTIVITY; STRIA TERMINALIS; ALCOHOL-SEEKING; BED NUCLEUS;

D O I：

10.3390/ph14050401

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The Neuropeptide S (NPS) system is a rather 'young' transmitter system that was discovered and functionally described less than 20 years ago. This review highlights the progress that has been made in elucidating its pharmacology, anatomical distribution, and functional involvement in a variety of physiological effects, including behavior and immune functions. Early on, genetic variations of the human NPS receptor (NPSR1) have attracted attention and we summarize current hypotheses of genetic linkage with disease and human behaviors. Finally, we review the therapeutic potential of future drugs modulating NPS signaling. This review serves as an introduction to the broad collection of original research papers and reviews from experts in the field that are presented in this Special Issue.

引用

页数：11

共 121 条

[21] Neuropeptide S receptor 1 gene polymorphism is associated with susceptibility to inflammatory bowel disease [J].

D'Amato, Mauro ;

Bruce, Sara ;

Bresso, Francesca ;

Zucchelli, Marco ;

Ezer, Sini ;

Pulkkinen, Ville ;

Lindgren, Cecilia ;

Astegiano, Marco ;

Rizzetto, Mario ;

Gionchetti, Paolo ;

Riegler, Gabriele ;

Sostegni, Raffaello ;

Daperno, Marco ;

D'Alfonso, Sandra ;

Momigliano-Richiardi, Patricia ;

Torkvist, Leif ;

Puolakkainen, Pauli ;

Lappalainen, Maarit ;

Paavola-Sakki, Paulina ;

Halme, Leena ;

Farkkila, Martti ;

Turunen, Ulla ;

Kontula, Kimmo ;

Lofbergh, Robert ;

Pettersson, Sven ;

Kere, Juha .

GASTROENTEROLOGY, 2007, 133 (03) :808-817

[22] Analysis of Neuropeptide S Receptor Gene (NPSR1) Polymorphism in Rheumatoid Arthritis [J].

D'Amato, Mauro ;

Zucchelli, Marco ;

Seddighzadeh, Maria ;

Anedda, Francesca ;

Lindblad, Staffan ;

Kere, Juha ;

Alfredsson, Lars ;

Klareskog, Lars ;

Padyukov, Leonid .

PLOS ONE, 2010, 5 (02)

[23] Neuropeptide-S (NPS) Receptor Genotype Modulates Basolateral Amygdala Responsiveness to Aversive Stimuli [J].

Dannlowski, Udo ;

Kugel, Harald ;

Franke, Friederike ;

Stuhrmann, Anja ;

Hohoff, Christa ;

Zwanzger, Peter ;

Lenzen, Thomas ;

Grotegerd, Dominik ;

Suslow, Thomas ;

Arolt, Volker ;

Heindel, Walter ;

Domschke, Katharina .

NEUROPSYCHOPHARMACOLOGY, 2011, 36 (09) :1879-1885

[24] A Single-Nucleotide Polymorphism of Human Neuropeptide S Gene Originated from Europe Shows Decreased Bioactivity [J].

Deng, Cheng ;

He, Ximiao ;

Hsueh, Aaron J. W. .

PLOS ONE, 2013, 8 (12)

[25] Neuropeptide S counteracts 6-OHDA-induced motor deficits in mice [J].

Didonet, Julia J. ;

Cavalcante, Judney C. ;

Souza, Lisiane de S. ;

Costa, Miriam S. M. O. ;

Andre, Eunice ;

Soares-Rachetti, Vanessa de P. ;

Guerrini, Remo ;

Calo, Girolamo ;

Gavioli, Elaine C. .

BEHAVIOURAL BRAIN RESEARCH, 2014, 266 :29-36

[26] Intranasally Applied Neuropeptide S Shifts a High-Anxiety Electrophysiological Endophenotype in the Ventral Hippocampus towards a "Normal"-Anxiety One [J].

Dine, Julien ;

Ionescu, Irina A. ;

Avrabos, Charilaos ;

Yen, Yi-Chun ;

Holsboer, Florian ;

Landgraf, Rainer ;

Schmidt, Ulrike ;

Eder, Matthias .

PLOS ONE, 2015, 10 (04)

[27] Neuropeptide S receptor gene-converging evidence for a role in panic disorder [J].

Domschke, K. ;

Reif, A. ;

Weber, H. ;

Richter, J. ;

Hohoff, C. ;

Ohrmann, P. ;

Pedersen, A. ;

Bauer, J. ;

Suslow, T. ;

Kugel, H. ;

Heindel, W. ;

Baumann, C. ;

Klauke, B. ;

Jacob, C. ;

Maier, W. ;

Fritze, J. ;

Bandelow, B. ;

Krakowitzky, P. ;

Rothermundt, M. ;

Erhardt, A. ;

Binder, E. B. ;

Holsboer, F. ;

Gerlach, A. L. ;

Kircher, T. ;

Lang, T. ;

Alpers, G. W. ;

Stroehle, A. ;

Fehm, L. ;

Gloster, A. T. ;

Wittchen, H-U ;

Arolt, V. ;

Pauli, P. ;

Hamm, A. ;

Deckert, J. .

MOLECULAR PSYCHIATRY, 2011, 16 (09) :938-948

[28] Assessment of the Neuropeptide S System in Anxiety Disorders [J].

Donner, Jonas ;

Haapakoski, Rita ;

Ezer, Sini ;

Melen, Erik ;

Pirkola, Sami ;

Gratacos, Monica ;

Zucchelli, Marco ;

Anedda, Francesca ;

Johansson, Lovisa E. ;

Soderhall, Cilla ;

Orsmark-Pietras, Christina ;

Suvisaari, Jaana ;

Martin-Santos, Rock ;

Torrens, Marta ;

Silander, Kaisa ;

Terwilliger, Joseph D. ;

Wickman, Magnus ;

Pershagen, Goran ;

Lonnqvist, Jouko ;

Peltonen, Leena ;

Estivill, Xavier ;

D'Amato, Mauro ;

Kere, Juha ;

Alenius, Harri ;

Hovatta, Iiris .

BIOLOGICAL PSYCHIATRY, 2010, 68 (05) :474-483

[29] Behavioral phenotyping of Neuropeptide S receptor knockout mice [J].

Duangdao, Dee M. ;

Clark, Stewart D. ;

Okamura, Naoe ;

Reinscheid, Rainer K. .

BEHAVIOURAL BRAIN RESEARCH, 2009, 205 (01) :1-9

[30] Increased in vivo release of neuropeptide S in the amygdala of freely moving rats after local depolarisation and emotional stress [J].

Ebner, Karl ;

Rjabokon, Alesja ;

Pape, Hans-Christian ;

Singewald, Nicolas .

AMINO ACIDS, 2011, 41 (04) :991-996

← 1 2 3 4 5 6 7 8 9 10 →