Tetrahedral framework nucleic acids act as antioxidants in acute kidney injury treatment

被引：76

作者：

Zhang, Qi ^{[1
]}

Lin, Shiyu ^{[2
]}

Wang, Lang ^{[3
]}

Peng, Shuanglin ^{[4
]}

Tian, Taoran ^{[1
]}

Li, Songhang ^{[1
]}

Xiao, Jingang ^{[4
]}

Lin, Yunfeng ^{[1
,5
]}

机构：

[1] Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu 610041, Peoples R China

[2] Zhejiang Univ, Affiliated Stomatol Hosp, Sch Med, Hangzhou 310003, Peoples R China

[3] Southwest Med Univ, Dept Oral Implantol, Affiliated Stomatol Hosp, Luzhou, Peoples R China

[4] Southwest Med Univ, Dept Oral & Maxillofacial Surg, Affiliated Stomatol Hosp, Luzhou, Peoples R China

[5] Sichuan Univ, Coll Biomed Engn, Chengdu 610041, Peoples R China

来源：

CHEMICAL ENGINEERING JOURNAL | 2021年 / 413卷

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

Tetrahedral framework nucleic acids; Oxidative stress; Acute kidney injury; Nrf2; HO-1; Nanomaterials; ACUTE-RENAL-FAILURE; OXIDATIVE STRESS; EPITHELIAL-CELLS; BLACK PHOSPHORUS; NANOPARTICLES; CLEARANCE; HEME; RHABDOMYOLYSIS; NANOSTRUCTURES; PROLIFERATION;

D O I：

10.1016/j.cej.2020.127426

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Antioxidants play an early intervention role in the pathogenesis of kidney injury by alleviating oxidative damage to the injured kidney. The development of safe and effective reactive oxygen species (ROS) scavengers for acute kidney injury (AKI) treatment is still worth exploring. Here, we presented tetrahedral framework nucleic acids (tFNAs) as a therapeutic drug for the treatment of rhabdomyolysis (RM)-AKI. tFNAs exhibited protective effects of cells mainly by relieving oxidative stress and inhibiting apoptosis. The features of tFNAs greatly facilitated kidney enrichment and decreased kidney injuries after injection in AKI models. Our findings showed that tFNAs constituted a novel class of antioxidative nanomaterials for AKI treatment with excellent antioxidant efficiency, superior structure stability, preferential kidney accumulation and good biocompatibility.

引用

页数：11

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