Betatrophin-Promises Fading and Lessons Learned

被引：19

作者：

Kaestner, Klaus H. ^{[1
,2
]}

机构：

[1] Univ Penn, Dept Genet, Perelman Sch Med, Philadelphia, PA 19104 USA

[2] Univ Penn, Inst Diabet Obes & Metab, Perelman Sch Med, Philadelphia, PA 19104 USA

来源：

CELL METABOLISM | 2014年 / 20卷 / 06期

关键词：

BETA-CELL REPLICATION; ANGPTL8/BETATROPHIN; MICE;

D O I：

10.1016/j.cmet.2014.11.016

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The discovery of a potent mitogen for insulin-producing pancreatic beta cells, optimistically termed "betatrophin," excited researchers and laypeople alike, promising a new therapeutic approach to diabetes. A recent "Matters Arising" report by Gusarova and colleagues (2014) places serious doubts on whether "betatrophin" plays any major role in b cell replication.

引用

页码：932 / 933

页数：2

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