CAR-NK cells: the next wave of cellular therapy for cancer

被引：89

作者：

Daher, May ^{[1
]}

Garcia, Luciana Melo ^{[1
]}

Li, Ye ^{[1
]}

Rezvani, Katayoun ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat & Cellular Therapy, 1515 Holcombe Blvd,Unit 423, Houston, TX 77030 USA

来源：

CLINICAL & TRANSLATIONAL IMMUNOLOGY | 2021年 / 10卷 / 04期

关键词：

allogeneic; cancer immunotherapy; CAR; cellular therapy; NK cells; off-the-shelf product; CHIMERIC ANTIGEN RECEPTOR; NK-92; EXPRESSION; RESISTANCE; CD19;

D O I：

10.1002/cti2.1274

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T cells engineered to express chimeric antigen receptors (CARs) have revolutionised the field of cellular therapy for cancer. Despite its success, this strategy has some recognised limitations and toxicities. Hence, there is growing interest in developing novel cellular therapies based on non-alpha beta T-cell immune effector cells, including NK cells that offer clear advantages in cancer immunotherapy. As a result, NK cells are being explored as an alternative platform for CAR engineering and are becoming recognised as important players in the next generation of cellular therapies targeting cancer. In this review, we highlight preclinical and clinical studies of CAR-NK cells derived from different sources and discuss strategies under investigation to enhance the antitumor activity of these engineered innate immune cells.

引用

页数：16

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