Phylogenetic groups and virulence factors of Escherichia coli strains causing pyelonephritis in children with and without urinary tract abnormalities

被引：13
作者：
Houdouin, V.
Bonacorsi, S.
Mahjoub-Messai, F.
Mariani-Kurkdjian, P.
Bidet, P.
Sebag, G.
Loirat, C.
Bourrillon, A.
Bingen, E.
机构：
[1] Hop Robert Debre, Serv Pediat Gen, AP HP, F-75395 Paris 19, France
[2] Hop Robert Debre, Serv Imagerie Med, AP HP, F-75395 Paris 19, France
[3] Hop Robert Debre, Serv Nephrol, AP HP, F-75395 Paris 19, France
[4] Univ Paris 07, Lab Etud Genet Bacterienne Infect Enfant, EA3105, Microbiol Serv, Paris, France
来源：
CLINICAL MICROBIOLOGY AND INFECTION | 2007年 / 13卷 / 07期
关键词：
anatomical abnormalities; Escherichia coli; phylogenetic groups; pyelonephritis; urinary tract infection; virulence factors;
D O I：
10.1111/j.1469-0691.2007.01748.x
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Escherichia coli isolates causing acute pyelonephritis in 93 children (25% with urinary tract abnormalities) were tested for nine virulence factors (papC, papGII, papGIII, sfa/foc, hlyC, cnf1, iucC, fyuA and iroN) and their phylogenetic groups were determined. Isolates lacking papGII were more frequent among patients with urinary tract abnormalities (58% vs. 10%, p 0.0003), as were non-virulent phylogenetic group A isolates (25% vs. 5%, p 0.043). Pyelonephritis caused by less virulent E. coli strains was more frequent among patients with significant urinary tract abnormalities. Further studies are required to determine whether screening for E. coli virulence factors may help to identify children warranting anatomical investigations.
引用
收藏
页码：740 / 742
页数：3
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