Expression of α1-acid glycoprotein and inflammatory cytokines during differentiation of HL-60 cells

被引:0
作者
Lee, IH [1 ]
Kim, IS [1 ]
Lee, SY [1 ]
机构
[1] Catholic Univ Korea, Coll Med, Dept Nat Sci, Chem Sect, Seoul 137701, South Korea
来源
JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2000年 / 33卷 / 05期
关键词
all-trans retinoic acid; alpha(1)-acid glycoprotein; cytokines; differentiation; HL-60; cells;
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In order to understand the role of AGP on the differentiation of promyelocytic leukemia cells, the AGP expression and its relation to cytokines were investigated during granulocytic or monocytic differentiation of HL-60 cells. When HL-60 cells were treated with all-trans-retinoic acid (ATRA) for 5 days, the cells were fully differentiated into granulocytes, and the AGP mRNA and protein levels were continuously increased up to 5 days in a dose- and time- dependent manner. However, in the case of the monocytic differentiation of HL-60 cells by tetradeanoyl phorbol acetate (TPA), the AGP gene expression was not induced. In addition, IL-1 alpha, IL-1 beta, IL-6 and TNF-alpha mRNAs were also enhanced during granulocytic differentiation. These cytokine transcripts showed a peak level 3 days after the ATRA treatment. It decreased gradually thereafter, However, direct addition of recombinant cytokines (IL-1 beta, IL-6 and TNF-alpha) and dexamethasone to the HL-60 cell cultures showed no AGP induction. These findings suggest that the AGP and proinflammatory cytokines are expressed in ATRA-treated promyelocytic cells. However, these cytokines do not act as autocrine inducers on AGP expression. This fact implies that the AGP expression during granulocytic differentiation of HL-60 cells is induced through a signal pathway different from hepatocyte signaling in inflammation.
引用
收藏
页码:402 / 406
页数:5
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