Evaluation of acetophenone monooxygenase and alcohol dehydrogenase activities in different fungal strains by biotransformation of acetophenone derivatives

被引：15
作者：
Andrade, LH
Keppler, AF
Schoenlein-Crusius, IH
Porto, ALM
Comasseto, JV
机构：
[1] Univ Sao Paulo, Lab Quim Fina & Biocatalise, Inst Quim, BR-05508900 Sao Paulo, Brazil
[2] Inst Bot, Secao Micol & Liquenol, BR-04301903 Sao Paulo, Brazil
来源：
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC | 2004年 / 31卷 / 4-6期
基金：
巴西圣保罗研究基金会;
关键词：
biotransformation; Baeyer-Villiger oxidation; bioreduction; fungus; ketones; phenols; monooxygenase; dehydrogenase;
D O I：
10.1016/j.molcatb.2004.08.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Experimental conditions using whole cells to select fungal strains for specific bioreduction of ketones and formation of Baeyer-Villiger oxidation products were studied. Epicoccum nigrum SSP 1498 was effective in the bioreduction leading to the chiral alcohols in up to 98% enantiomeric excess. High acetophenone monooxygenase activity was observed by the use of the fungus Emericella nidulans CCT 3119 as biocatalyst. (C) 2004 Elsevier B.V. All rights reserved.
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收藏
页码：129 / 135
页数：7
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