Non-redundant roles for Th17 and Th22 cells in multiple myeloma clinical correlates

被引：12
|
作者：
Di Lullo, Giulia [1 ,2 ]
Marcatti, Magda [3 ]
Protti, Maria Pia [1 ,2 ]
机构：
[1] Ist Sci San Raffaele, IRCCS, Tumor Immunol Unit, I-20132 Milan, Italy
[2] Ist Sci San Raffaele, IRCCS, Div Immunol Transplantat & Infect Dis, I-20132 Milan, Italy
[3] Ist Sci San Raffaele, IRCCS, Hematol & Bone Marrow Transplantat Unit, I-20132 Milan, Italy
来源：
ONCOIMMUNOLOGY | 2016年 / 5卷 / 04期
关键词：
BM mesenchymal stromal cells; BM microenvironment; bone disease; disease prognosis; IL-13; IL-17; IL-22; multiple myeloma; Th17; cells; Th22; DENDRITIC CELLS; INTERLEUKIN; 22; BONE-DISEASE; IDENTIFICATION; SUBSET; T(H)17; MARROW; IMMUNE; IL-17;
D O I：
10.1080/2162402X.2015.1093278
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We recently reported that in multiple myeloma increased Th22 cell frequencies correlate with poor prognosis. Here we show that within the same patients' cohort Th17 cells associate with bone disease and not with prognosis. Thus, we propose that Th22 and Th17 cells play non-redundant roles in multiple myeloma and constitute independent therapeutic targets.
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页数：5
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