Factors influencing on quality of life in people with epilepsy

Objectives: To assess the influence of different factors on heatth-related QOL in adults with epilepsy in Moscow, Russia. Method: We evaluated quality of life in 242 patients (98 de novo and 144 previously inadequately treated) by using QOLIE-31. Partial cryptogenic or symptomatic epilepsy was diagnosed in 214 patients, in 28-idiopathic generalized epilepsy. Stepwise regression analysis was performed to assess the influence of different factors on QOL. Results: In patients with epilepsy in Russia the total score of QOLIE-31 was rather low - -42.13 +/- 4.14. Relationship of quality of life (total score) and frequency of seizures and duration of disease was analyzed. Frequency of seizures was the most significant parameter related to QOL (R = 0.46 with total score). Duration of disease also correlated with QOL score (R = 0.24 with total score). Significant but rather weak association (link) between frequency of seizures and almost all of subscales of quality of life was noticed. Duration of epilepsy correlated with less number of subscales: Energy/fatigue, Medication effects, Social functioning, Overall QOL subscales. When factors influencing on QOL were separately analyzed in newly diagnosed and previously treated patients frequency of seizures was the most important parameter in both groups. Conclusions: Frequency of seizures is the most important factor influencing on QOL in adults with epilepsy (newly diagnosed and previously treated). (C) 2006 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.