Palladium- and Nickel-Catalyzed Kumada Cross-Coupling Reactions of gem-Difluoroalkenes and Monofluoroalkenes with Grignard Reagents

被引：92

作者：

Dai, Wenpeng ^{[1
]}

Xiao, Juan ^{[1
]}

Jin, Guanyi ^{[1
]}

Wu, Jingjing ^{[2
,3
]}

Cao, Song ^{[1
,2
]}

机构：

[1] E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

[3] Shanghai Inst Technol, Sch Chem & Environm Engn, Shanghai 201418, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 79卷 / 21期

基金：

中国国家自然科学基金;

关键词：

ADDITION-ELIMINATION REACTIONS; C-F BOND; EXCHANGE-REACTION; ALKENYL HALIDES; ALKYL GRIGNARD; STEREOSELECTIVE-SYNTHESIS; ORGANIC HALIDES; COMPLEXES; ARYL; GENERATION;

D O I：

10.1021/jo5022234

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel Kumada-Tamao-Corriu cross-coupling reaction of gem-di- or monofluoroalkenes with Grignard reagents, with or without beta-hydrogen atoms, in the presence of a catalytic amount of palladium- or nickel-based catalysts has been developed. The reaction is performed under mild conditions (room temperature or reflux in diethyl ether for 1-2 h) and leads to di-cross- or mono-cross-coupled products in good to high yields.

引用

页码：10537 / 10546

页数：10