Sustained release and enhanced bioavailability of injectable scutellarin-loaded bovine serum albumin nanoparticles

被引：47

作者：

Wei, Yuanfeng ^{[1
]}

Li, Laicun ^{[1
]}

Xi, Yifeng ^{[1
]}

Qian, Shuai ^{[1
]}

Gao, Yuan ^{[1
]}

Zhang, Jianjun ^{[2
]}

机构：

[1] China Pharmaceut Univ, Sch Tradit Chinese Med, Nanjing 210009, Jiangsu, Peoples R China

[2] China Pharmaceut Univ, Dept Pharmaceut, Nanjing 210009, Jiangsu, Peoples R China

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2014年 / 476卷 / 1-2期

关键词：

Scutellarin; Albumin nanoparticles; Sustained release; Elimination half-life; Bioavailability; DRUG-DELIVERY; CELL LINES; BREVISCAPINE; RATS; PHARMACOKINETICS; DISSOLUTION; PROFILES; DESIGN; BRAIN;

D O I：

10.1016/j.ijpharm.2014.09.038

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aim of this study is to characterize the in-vitro physicochemical and in-vivo pharmacokinetic properties of the scutellarin-loaded bovine serum albumin nanoparticles (STA-BSA-NPs). STA existed as amorphous form in the nanoparticles. Reconstituted STA-BSA-NPs had an average particle size of 283.4 nm and a zeta potential of +17.95 mV. The in-vitro sustained release profile was well fitted with Weibull distribution model. In comparison to STA solution, STA-BSA-NPs exhibited a significantly higher plasma concentration from 20 min to 6 h after intravenous administration to rats. In addition, significantly higher AUC(0-inf) (2.8-fold), prolonged elimination half-life (4.2-fold) and lower clearance (2.7-fold) were achieved. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：142 / 148

页数：7

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