Myocardial Expression of SERCA2a and Structural and Functional Indices in Patients with Atrial Fibrillation

被引：2
作者：
Kondrat'eva, D. S. [1 ]
Afanas'ev, S. A. [1 ]
Archakov, E. A. [1 ]
Tsapko, L. P. [1 ]
Batalov, R. E. [1 ]
机构：
[1] Russian Acad Sci, Tomsk Natl Res Med Ctr, Res Inst Cardiol, Tomsk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2019年 / 167卷 / 06期
关键词：
atrial fibrillation; SERCA2a expression; echocardiography;
D O I：
10.1007/s10517-019-04623-9
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The study examined the relationships between SERCA2a expression in the myocardium and structural and functional indices in patients with atrial fibrillation. In uniform cohort of patients, this expression differed significantly but positively correlated with the size of the left atrium, end-systolic volume, and end-diastolic volume. In contrast, SERCA2a expression negatively correlated with early (peak E) and late (peak A) diastolic filling rates in left ventricle. SERCA2a expression was also associated with echocardiographic parameters reflecting structural and functional status of the heart in patients with persistent atrial fibrillation.
引用
收藏
页码：787 / 790
页数：4
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