Accumulation of Trans-1-Amino-3-[18F]Fluorocyclobutanecarboxylic Acid in Prostate Cancer due to Androgen-Induced Expression of Amino Acid Transporters

被引：30
作者：
Okudaira, Hiroyuki [1 ]
Oka, Shuntaro [1 ]
Ono, Masahiro [1 ,2 ]
Nakanishi, Takeo [3 ]
Schuster, David M. [4 ]
Kobayashi, Masato [2 ]
Goodman, Mark M. [4 ]
Tamai, Ikumi [3 ]
Kawai, Keiichi [2 ,5 ]
Shirakami, Yoshifumi [1 ]
机构：
[1] Nihon Medi Phys Co Ltd, Res Ctr, Chiba 2990266, Japan
[2] Kanazawa Univ, Grad Sch Med Sci, Div Hlth Sci, Kanazawa, Ishikawa 9201192, Japan
[3] Kanazawa Univ, Fac Pharmaceut Sci, Dept Membrane Transport & Biopharmaceut, Kanazawa, Ishikawa 9201192, Japan
[4] Emory Univ, Dept Radiol & Imaging Sci, Div Nucl Med & Mol Imaging, Atlanta, GA 30322 USA
[5] Univ Fukui, Biomed Imaging Res Ctr, Fukui 910, Japan
来源：
MOLECULAR IMAGING AND BIOLOGY | 2014年 / 16卷 / 06期
关键词：
anti-FACBC; Prostate cancer; Androgen; Amino acid transporter; ASCT2; ANTI-1-AMINO-3-F-18-FLUOROCYCLOBUTANE-1-CARBOXYLIC ACID; CELL-GROWTH; PET/CT; RECEPTOR; IDENTIFICATION; MECHANISMS; CARCINOMA; ASCT2; LAT1;
D O I：
10.1007/s11307-014-0756-x
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Androgens play a crucial role in prostate cancer progression, and trans-1-amino-3-[F-18]fluorocyclobutanecarboxylic acid (anti-[(18) F]FACBC) are used for visualization of prostate cancer. We examined the effect of androgen on the expression of amino acid transporters related to anti-[F-18]FACBC transport and uptake of trans-1-amino-3-fluoro-[1-C-14]cyclobutanecarboxylic acid (anti-[C-14]FACBC). Expression of amino acid transporters and uptake of anti-[C-14]FACBC in androgen receptor (AR)-positive LNCaP and AR-negative DU145 human prostate cancer cells cultured with/without 5 alpha-dihydrotestosterone (DHT) and the effect of bicalutamide, an AR antagonist, on DHT-associated changes were investigated. DHT stimulated the expression of amino acid transporters ASCT2, SNAT5, 4F2 heavy chain, and LAT3 in LNCaP but not in DU145 cells. Anti-[C-14]FACBC uptake was enhanced, in a DHT-dependent manner, in LNCaP cells only. DHT enhanced the expression of ASCT2, the transporter responsible for anti-[F-18]FACBC uptake, thereby increasing anti-[C-14]FACBC uptake in AR-positive LNCaP cells. Androgen-mediated induction may contribute to the distinct anti-[F-18]FACBC accumulation pattern in prostate cancer.
引用
收藏
页码：756 / 764
页数：9
相关论文
共 34 条
  • [1] Genomic regulation of intestinal amino acid transporters by aldosterone
    Amaral, Joao S.
    Pinho, Maria Joao
    Soares-da-Silva, Patricio
    [J]. MOLECULAR AND CELLULAR BIOCHEMISTRY, 2008, 313 (1-2) : 1 - 10
  • [2] Enhanced expression of organic anion transporting polypeptides (OATPs) in androgen receptor-positive prostate cancer cells: Possible role of OATP1A2 in adaptive cell growth under androgen-depleted conditions
    Arakawa, Hiroshi
    Nakanishi, Takeo
    Yanagihara, Chihiro
    Nishimoto, Tomohiro
    Wakayama, Tomohiko
    Mizokami, Atsushi
    Narniki, Mikio
    Kawai, Keiichi
    Tamai, Ikumi
    [J]. BIOCHEMICAL PHARMACOLOGY, 2012, 84 (08) : 1070 - 1077
  • [3] Phase I clinical study of NMK36: a new PET tracer with the synthetic amino acid analogue anti-[18F]FACBC
    Asano, Yuji
    Inoue, Yusuke
    Ikeda, Yasuhiko
    Kikuchi, Kei
    Hara, Toshimasa
    Taguchi, Chikako
    Tokushige, Takanori
    Maruo, Hideki
    Takeda, Tohoru
    Nakamura, Tomomi
    Fujita, Tomoe
    Kumagai, Yuji
    Hayakawa, Kazushige
    [J]. ANNALS OF NUCLEAR MEDICINE, 2011, 25 (06) : 414 - 418
  • [4] Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters
    Babu, E
    Kanai, Y
    Chairoungdua, A
    Kim, DK
    Iribe, Y
    Tangtrongsup, S
    Jutabha, P
    Li, YW
    Ahmed, N
    Sakamoto, S
    Anzai, N
    Nagamori, S
    Endou, H
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (44) : 43838 - 43845
  • [5] CD98 at the crossroads of adaptive immunity and cancer
    Cantor, Joseph M.
    Ginsberg, Mark H.
    [J]. JOURNAL OF CELL SCIENCE, 2012, 125 (06) : 1373 - 1382
  • [6] Androgen-regulated genes in the murine epididymis
    Chauvin, TR
    Griswold, MD
    [J]. BIOLOGY OF REPRODUCTION, 2004, 71 (02) : 560 - 569
  • [7] Identification of a novel transcript up-regulated in a clinically aggressive prostate carcinoma
    Chuaqui, RF
    Englert, CR
    Strup, SE
    Vocke, CD
    Zhuang, ZP
    Duray, PH
    Bostwick, DG
    Linehan, WM
    Liotta, LA
    EmmertBuck, MR
    [J]. UROLOGY, 1997, 50 (02) : 302 - 307
  • [8] Molecular mechanisms of castration-resistant prostate cancer progression
    Dutt, Smitha S.
    Gao, Allen C.
    [J]. FUTURE ONCOLOGY, 2009, 5 (09) : 1403 - 1413
  • [9] The development of androgen-independent prostate cancer
    Feldman, BJ
    Feldman, D
    [J]. NATURE REVIEWS CANCER, 2001, 1 (01) : 34 - 45
  • [10] Amino acid transporters ASCT2 and LAT1 in cancer: Partners in crime?
    Fuchs, BC
    Bode, BP
    [J]. SEMINARS IN CANCER BIOLOGY, 2005, 15 (04) : 254 - 266
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