Lung Nodule Detection using Convolutional Neural Networks with Transfer Learning on CT Images

Aim and Objective: Lung nodule detection is critical in improving the five-year survival rate and reducing mortality for patients with lung cancer. Numerous methods based on Convolutional Neural Networks (CNNs) have been proposed for lung nodule detection in Computed Tomography (CT) images. With the collaborative development of computer hardware technology, the detection accuracy and efficiency can still be improved. Materials and Methods: In this study, an automatic lung nodule detection method using CNNs with transfer learning is presented. We first compared three of the state-of-the-art convolutional neural network (CNN) models, namely, VGG16, VGG19 and ResNet50, to determine the most suitable model for lung nodule detection. We then utilized two different training strategies, namely, freezing layers and fine-tuning, to illustrate the effectiveness of transfer learning. Furthermore, the hyper-parameters of the CNN model such as optimizer, batch size and epoch were optimized. Results: Evaluated on the Lung Nodule Analysis 2016 (LUNA16) challenge, promising results with an accuracy of 96.86%, a precision of 91.10%, a sensitivity of 90.78%, a specificity of 98.13%, and an AUC of 99.37% were achieved. Conclusion: Compared with other works, state-of-the-art specificity is obtained, which demonstrates that the proposed method is effective and applicable to lung nodule detection.