The mimivirus genome encodes a mitochondrial carrier that transports dATP and dTTP

被引：26

作者：

Monne, Magnus ^{[1
]}

Robinson, Alan J. ^{[1
]}

Boes, Christoph ^{[1
]}

Harbour, Michael E. ^{[1
]}

Fearnley, Ian M. ^{[1
]}

Kunji, Edmund R. S. ^{[1
]}

机构：

[1] MRC, Dunn Human Nutr Unit, Cambridge CB2 2XY, England

来源：

JOURNAL OF VIROLOGY | 2007年 / 81卷 / 07期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1128/JVI.02386-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Members of the mitochondrial carrier family have been reported in eukaryotes only, where they transport metabolites and cofactors across the mitochondrial inner membrane to link the metabolic pathways of the cytosol and the matrix. The genome of the giant virus Mimiviridae mimivirus encodes a member of the mitochondrial carrier family of transport proteins. This viral protein has been expressed in Lactococcus lactis and is shown to transport dATP and dTTP. As the 1.2-Mb double-stranded DNA mimivirus genome is rich in A and T residues, we speculate that the virus is using this protein to target the host mitochondria as a source of deoxynucleotides for its replication.

引用

页码：3181 / 3186

页数：6

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