Light-emitting diodes in photodynamic therapy in non-melanoma skin cancers - own observations and literature review

被引：25

作者：

Erkiert-Polguj, Anna ^{[1
]}

Halbina, Adam ^{[2
]}

Polak-Pacholczyk, Izabela ^{[2
]}

Rotsztejn, Helena ^{[1
,2
]}

机构：

[1] Univ Lodz, Dept Cosmetol & Aesthet Dermatol, PL-90131 Lodz, Poland

[2] Dermed Med Ctr, Lodz, Poland

来源：

JOURNAL OF COSMETIC AND LASER THERAPY | 2016年 / 18卷 / 02期

关键词：

photodynamic therapy; light-emitting diodes; basal cell carcinoma; Actinic keratosis; TOPICAL METHYL AMINOLEVULINATE; BASAL-CELL CARCINOMA; 5-AMINOLEVULINIC ACID; ACTINIC KERATOSES; BF-200; ALA; PHASE-III; FOLLOW-UP; BOWENS-DISEASE; RED; PDT;

D O I：

10.3109/14764172.2015.1114635

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Photodynamic therapy (PDT) employs light activation of tissue-localized photosensitizer in an oxygen-dependent process which initiates oxidative stress, inflammation, and cell death. There are many indications for PDT, although the main ones are still non-melanoma skin cancers. The light sources used include coherent and non-coherent ones, but we would like to focus on the use of light-emitting diodes (LED) in PDT. We present four patients with skin lesions successfully treated with LED-based photodynamic therapy. The main advantage of that source is narrow emission spectrum that can correspond well with maximum absorption photosensitizers. Also, using LED source seems to be cheaper and simpler, and the field of irradiation is larger. The data showed good clinical and cosmetic outcome of LED-based PDT in actinic keratosis, basal cell carcinoma, and Bowen's disease. Since these diseases often appear on sun-exposed skin, aesthetic results are very important. The effect of LED treatment is as good or in some data even better than those in older types of PDT.

引用

页码：105 / 110

页数：6

共 33 条

[1] An open pilot study of ambulatory photodynamic therapy using a wearable low-irradiance organic light-emitting diode light source in the treatment of nonmelanoma skin cancer [J].

Attili, S. K. ;

Lesar, A. ;

McNeill, A. ;

Camacho-Lopez, M. ;

Moseley, H. ;

Ibbotson, S. ;

Samuel, I. D. W. ;

Ferguson, J. .

BRITISH JOURNAL OF DERMATOLOGY, 2009, 161 (01) :170-173

[2] Variable pulsed light is less painful than light-emitting diodes for topical photodynamic therapy of actinic keratosis: a prospective randomized controlled trial [J].

Babilas, P. ;

Knobler, R. ;

Hummel, S. ;

Gottschaller, C. ;

Maisch, T. ;

Koller, M. ;

Landthaler, M. ;

Szeimies, R.-M. .

BRITISH JOURNAL OF DERMATOLOGY, 2007, 157 (01) :111-117

[3] In vitro and in vivo comparison of two different light sources for topical photodynamic therapy [J].

Babilas, P ;

Kohl, E ;

Maisch, T ;

Bäcker, H ;

Gross, B ;

Branzan, AL ;

Bäumler, W ;

Landthaler, M ;

Karrer, S ;

Szeimies, RM .

BRITISH JOURNAL OF DERMATOLOGY, 2006, 154 (04) :712-718

[4] Split-face study using two different light sources for topical PDT of actinic keratoses: non-inferiority of the LED-system [J].

Babilas, Philipp ;

Travnik, Richard ;

Werner, Annegret ;

Landthaler, Michael ;

Szeimies, Rolf-Markus .

JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, 2008, 6 (01) :25-33

[5] Non-melanoma skin cancers: Photodynamic therapy, cryotherapy, 5-fluorouracil, imiquimod, diclofenac, or what? Facts and controversies [J].

Bahner, Jennifer D. ;

Bordeaux, Jeremy S. .

CLINICS IN DERMATOLOGY, 2013, 31 (06) :792-798

[6] High and sustained efficacy after two sessions of topical 5-aminolaevulinic acid photodynamic therapy for basal cell carcinoma: a prospective, clinical and histological 10-year follow-up study [J].

Christensen, E. ;

Mork, C. ;

Skogvoll, E. .

BRITISH JOURNAL OF DERMATOLOGY, 2012, 166 (06) :1342-1348

[7] Topical 5-aminolaevulinic acid photodynamic therapy for cutaneous lesions: outcome and comparison of light sources [J].

Clark, C ;

Bryden, A ;

Dawe, R ;

Moseley, H ;

Ferguson, J ;

Ibbotson, SH .

PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE, 2003, 19 (03) :134-141

[8] Guidelines for the management of actinic keratoses [J].

de Berker, D. ;

McGregor, J. M. ;

Hughes, B. R. .

BRITISH JOURNAL OF DERMATOLOGY, 2007, 156 (02) :222-230

[9] Long-term (6 and 12 months) follow-up of two prospective, randomized, controlled phase III trials of photodynamic therapy with BF-200 ALA and methyl aminolaevulinate for the treatment of actinic keratosis [J].

Dirschka, T. ;

Radny, P. ;

Dominicus, R. ;

Mensing, H. ;

Bruening, H. ;

Jenne, L. ;

Karl, L. ;

Sebastian, M. ;

Oster-Schmidt, C. ;

Kloevekorn, W. ;

Reinhold, U. ;

Tanner, M. ;

Groene, D. ;

Deichmann, M. ;

Simon, M. ;

Huebinger, F. ;

Hofbauer, G. ;

Kraehn-Senftleben, G. ;

Borrosch, F. ;

Reich, K. ;

Berking, C. ;

Wolf, P. ;

Lehmann, P. ;

Moers-Carpi, M. ;

Hoenigsmann, H. ;

Wernicke-Panten, K. ;

Hahn, S. ;

Pabst, G. ;

Voss, D. ;

Foguet, M. ;

Schmitz, B. ;

Luebbert, H. ;

Szeimies, R. -M. .

BRITISH JOURNAL OF DERMATOLOGY, 2013, 168 (04) :825-836

[10] Photodynamic therapy with BF-200 ALA for the treatment of actinic keratosis: results of a multicentre, randomized, observer-blind phase III study in comparison with a registered methyl-5-aminolaevulinate cream and placebo [J].