Combining Epigenetic and Immunotherapy to Combat Cancer

被引：244

作者：

Chiappinelli, Katherine B. ^{[1
]}

Zahnow, Cynthia A. ^{[1
]}

Ahuja, Nita ^{[1
]}

Baylin, Stephen B. ^{[1
]}

机构：

[1] Sidney Kimmel Comprehens Canc Ctr Johns Hopkins, Dept Oncol, Baltimore, MD USA

来源：

CANCER RESEARCH | 2016年 / 76卷 / 07期

关键词：

HISTONE DEACETYLASE INHIBITORS; CELL LUNG-CANCER; OVARIAN-CANCER; DNA METHYLATION; CTLA-4; BLOCKADE; ENDOGENOUS RETROVIRUSES; IMMUNOMODULATORY ACTION; INTERFERON RESPONSE; GENE-EXPRESSION; IMMUNE EVASION;

D O I：

10.1158/0008-5472.CAN-15-2125

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The most exciting recent advance for achieving durable management of advanced human cancers is immunotherapy, especially the concept of immune checkpoint blockade. However, with the exception of melanoma, most patients do not respond to immunotherapy alone. A growing body of work has shown that epigenetic drugs, specifically DNA methyltransferase inhibitors, can upregulate immune signaling in epithelial cancer cells through demethylation of endogenous retroviruses and cancer testis antigens. These demethylating agents may induce T-cell attraction and enhance immune checkpoint inhibitor efficacy in mouse models. Current clinical trials are testing this combination therapy as a potent new cancer management strategy.

引用

页码：1683 / 1689

页数：7

共 76 条

[31] Limited gene activation in tumor and normal epithelial cells treated with the DNA methyltransferase inhibitor 5-aza-2′-deoxycytidine [J].

Karpf, AR ;

Lasek, AW ;

Ririe, TO ;

Hanks, AN ;

Grossman, D ;

Jones, DA .

MOLECULAR PHARMACOLOGY, 2004, 65 (01) :18-27

[32] Decitabine has a biphasic effect on natural killer cell viability, phenotype, and function under proliferative conditions [J].

Kopp, Lisa M. ;

Ray, Anish ;

Denman, Cecele J. ;

Senyukov, Vladimir S. ;

Somanchi, Srinivas S. ;

Zhu, Shiguo ;

Lee, Dean A. .

MOLECULAR IMMUNOLOGY, 2013, 54 (3-4) :296-301

[33] Genetic Engineering of T Cells to Target HERV-K, an Ancient Retrovirus on Melanoma [J].

Krishnamurthy, Janani ;

Rabinovich, Brian A. ;

Mi, Tiejuan ;

Switzer, Kirsten C. ;

Olivares, Simon ;

Maiti, Sourindra N. ;

Plummer, Joshua B. ;

Singh, Harjeet ;

Kumaresan, Pappanaicken R. ;

Huls, Helen M. ;

Wang-Johanning, Feng ;

Cooper, Laurence J. N. .

CLINICAL CANCER RESEARCH, 2015, 21 (14) :3241-3251

[34] Epigenetic mechanisms of regulation of Foxp3 expression [J].

Lal, Girdhari ;

Bromberg, Jonathan S. .

BLOOD, 2009, 114 (18) :3727-3735

[35] Enhancement of antitumor immunity by CTLA-4 blockade [J].

Leach, DR ;

Krummel, MF ;

Allison, JP .

SCIENCE, 1996, 271 (5256) :1734-1736

[36] p53 cooperates with DNA methylation and a suicidal interferon response to maintain epigenetic silencing of repeats and noncoding RNAs [J].

Leonova, Katerina I. ;

Brodsky, Leonid ;

Lipchick, Brittany ;

Pal, Mahadeb ;

Novototskaya, Liliya ;

Chenchik, Alex A. ;

Sen, Ganes C. ;

Komarova, Elena A. ;

Gudkov, Andrei V. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (01) :E89-E98

[37] Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers [J].

Li, Huili ;

Chiappinelli, Katherine B. ;

Guzzetta, Angela A. ;

Easwaran, Hariharan ;

Yen, Ray-Whay Chiu ;

Vatapalli, Rajita ;

Topper, Michael J. ;

Luo, Jianjun ;

Connolly, Roisin M. ;

Azad, Nilofer S. ;

Stearns, Vered ;

Pardoll, Drew M. ;

Davidson, Nancy ;

Jones, Peter A. ;

Slamon, Dennis J. ;

Baylin, Stephen B. ;

Zahnow, Cynthia A. ;

Ahuja, Nita .

ONCOTARGET, 2014, 5 (03) :587-598

[38] Epigenetic Silencing of IRF7 and/or IRF5 in Lung Cancer Cells Leads to Increased Sensitivity to Oncolytic Viruses [J].

Li, Qunfang ;

Tainsky, Michael A. .

PLOS ONE, 2011, 6 (12)

[39] The histone deacetylase inhibitor, LBH589, promotes the systemic cytokine and effector responses of adoptively transferred CD8+ T cells [J].

Lisiero, Dominique N. ;

Soto, Horacio ;

Everson, Richard G. ;

Liau, Linda M. ;

Prins, Robert M. .

JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2014, 2

[40] Epigenetic Resensitization to Platinum in Ovarian Cancer [J].

Matei, Daniela ;

Fang, Fang ;

Shen, Changyu ;

Schilder, Jeanne ;

Arnold, Alesha ;

Zeng, Yan ;

Berry, William A. ;

Huang, Tim ;

Nephew, Kenneth P. .

CANCER RESEARCH, 2012, 72 (09) :2197-2205

← 1 2 3 4 5 6 7 8 →