Eosinophil and T cell markers predict functional decline in COPD patients

被引：38

作者：

D'Armiento, Jeanine M. ^{[1
,2
]}

Scharf, Steven M. ^{[3
]}

Roth, Michael D. ^{[4
,5
]}

Connett, John E. ^{[6
,7
]}

Ghio, Andrew ^{[8
]}

Sternberg, David ^{[1
,2
]}

Goldin, Jonathan G. ^{[4
,5
]}

Louis, Thomas A. ^{[9
]}

Mao, Jenny T. ^{[4
,5
]}

O'Connor, George T. ^{[10
]}

Ramsdell, Joe W. ^{[11
]}

Ries, Andrew L. ^{[11
]}

Schluger, Neil W. ^{[1
,2
]}

Sciurba, Frank C. ^{[12
]}

Skeans, Melissa A. ^{[4
,5
]}

Voelker, Helen ^{[4
,5
]}

Walter, Robert E. ^{[9
]}

Wendt, Christine H. ^{[4
,5
]}

Weinmann, Gail G. ^{[13
]}

Wise, Robert A. ^{[8
]}

Foronjy, Robert F. ^{[1
,2
]}

机构：

[1] Columbia Univ, Dept Med, New York, NY 10027 USA

[2] Columbia Univ, Dept Surg, New York, NY USA

[3] Univ Maryland, Dept Med, Baltimore, MD 21201 USA

[4] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90024 USA

[5] Univ Calif Los Angeles, Dept Biol, Los Angeles, CA 90024 USA

[6] Univ Minnesota, Dept Med, CCBR, Twin Cities, CA USA

[7] Univ Minnesota, Dept Biostat, CCBR, Twin Cities, CA USA

[8] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA

[9] Johns Hopkins Univ, Dept Med, Baltimore, MD USA

[10] Boston Univ, Dept Med, Boston, MA 02215 USA

[11] Univ Calif San Diego, Dept Med, San Diego, CA 92103 USA

[12] Univ Pittsburgh, Dept Med, Pittsburgh, PA USA

[13] NIH, Bethesda, MD 20892 USA

来源：

RESPIRATORY RESEARCH | 2009年 / 10卷

关键词：

OBSTRUCTIVE PULMONARY-DISEASE; CIGARETTE-SMOKE; AIRWAY INFLAMMATION; RESPIRATORY VIRUSES; EFFECTOR ACTIVITY; APOPTOSIS; MEMORY; EXACERBATIONS; LYMPHOCYTES; RESPONSES;

D O I：

10.1186/1465-9921-10-113

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Background: The major marker utilized to monitor COPD patients is forced expiratory volume in one second (FEV1). However, asingle measurement of FEV1 cannot reliably predict subsequent decline. Recent studies indicate that T lymphocytes and eosinophils are important determinants of disease stability in COPD. We therefore measured cytokine levels in the lung lavage fluid and plasma of COPD patients in order to determine if the levels of T cell or eosinophil related cytokines were predictive of the future course of the disease. Methods: Baseline lung lavage and plasma samples were collected from COPD subjects with moderately severe airway obstruction and emphysematous changes on chest CT. The study participants were former smokers who had not had a disease exacerbation within the past six months or used steroids within the past two months. Those subjects who demonstrated stable disease over the following six months (Delta FEV1 % predicted = 4.7 +/- 7.2; N = 34) were retrospectively compared with study participants who experienced a rapid decline in lung function (Delta FEV1 % predicted = -16.0 +/- 6.0; N = 16) during the same time period and with normal controls (N = 11). Plasma and lung lavage cytokines were measured from clinical samples using the Luminex multiplex kit which enabled the simultaneous measurement of several T cell and eosinophil related cytokines. Results and Discussion: Stable COPD participants had significantly higher plasma IL-2 levels compared to participants with rapidly progressive COPD (p = 0.04). In contrast, plasma eotaxin-1 levels were significantly lower in stable COPD subjects compared to normal controls (p < 0.03). In addition, lung lavage eotaxin-1 levels were significantly higher in rapidly progressive COPD participants compared to both normal controls (p < 0.02) and stable COPD participants (p < 0.05). Conclusion: These findings indicate that IL-2 and eotaxin-1 levels may be important markers of disease stability in advanced emphysema patients. Prospective studies will need to confirm whether measuring IL-2 or eotaxin-1 can identify patients at risk for rapid disease progression.

引用

页数：13

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