Nanoparticles in Medicine: A Focus on Vascular Oxidative Stress

被引：124

作者：

Mauricio, M. D. ^{[1
,2
]}

Guerra-Ojeda, S. ^{[1
,2
]}

Marchio, P. ^{[1
,2
]}

Valles, S. L. ^{[1
,2
]}

Aldasoro, M. ^{[1
,2
]}

Escribano-Lopez, I. ^{[3
]}

Herance, J. R. ^{[4
]}

Rocha, M. ^{[3
]}

Vila, J. M. ^{[1
,2
]}

Victor, V. M. ^{[1
,2
,3
]}

机构：

[1] Univ Valencia, Dept Physiol, Fac Med & Odontol, Valencia, Spain

[2] Inst Hlth Res INCLIVA, Valencia, Spain

[3] Univ Hosp Doctor Peset, Fdn Promot Hlth & Biomed Res Valencian Reg FISABI, Serv Endocrinol, Valencia, Spain

[4] Vall Hebron Res Inst VHIR, CIBBIM Nanomed, Med Mol Imaging Res Grp, Barcelona, Spain

来源：

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2018年 / 2018卷

关键词：

NITRIC-OXIDE SYNTHASE; SMOOTH-MUSCLE-CELLS; MESOPOROUS SILICA NANOPARTICLES; ENDOTHELIAL NO SYNTHASE; NADPH OXIDASE; DRUG-DELIVERY; XANTHINE-OXIDASE; POLYMERIC NANOPARTICLES; SILVER NANOPARTICLES; SUPEROXIDE-DISMUTASE;

D O I：

10.1155/2018/6231482

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Nanotechnology has had a significant impact on medicine in recent years, its application being referred to as nanomedicine. Nanoparticles have certain properties with biomedical applications; however, in some situations, they have demonstrated cell toxicity, which has caused concern surrounding their clinical use. In this review, we focus on two aspects: first, we summarize the types of nanoparticles according to their chemical composition and the general characteristics of their use in medicine, and second, we review the applications of nanoparticles in vascular alteration, especially in endothelial dysfunction related to oxidative stress. This condition can lead to a reduction in nitric oxide (NO) bioavailability, consequently affecting vascular tone regulation and endothelial dysfunction, which is the first phase in the development of cardiovascular diseases. Therefore, nanoparticles with antioxidant properties may improve vascular dysfunction associated with hypertension, diabetes mellitus, or atherosclerosis.

引用

页数：20

共 191 条

[1] Pristine simple oxides as visible light driven photocatalysts: Highly efficient decomposition of organic compounds over platinum-loaded tungsten oxide [J].