Palladium-Catalyzed Spirocyclization through C-H Activation and Regioselective Alkyne Insertion

被引：125
|
作者：
Yoon, Hyung [1 ]
Rolz, Martin [1 ]
Landau, Felicitas [1 ]
Lautens, Mark [1 ]
机构：
[1] Univ Toronto, Davenport Chem Labs, Dept Chem, 80 St George St, Toronto, ON M5S 3H6, Canada
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2017年 / 56卷 / 36期
基金：
加拿大自然科学与工程研究理事会;
关键词：
alkynes; C-H activation; palladium; regioselectivity; spiro compounds; C(SP(2))-H BOND ACTIVATION; EFFICIENT SYNTHESIS; DOMINO REACTION; HECK REACTION; FUNCTIONALIZATION; OXINDOLES; ALKYLATION; C(SP(3))-H; MIGRATION; ARYLATION;
D O I：
10.1002/anie.201706325
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A Pd-catalyzed spirocyclization involving a sequential carbopalladation, intramolecular C-H activation, and a highly regioselective alkyne insertion to afford spirooxindoles and spirodihydrobenzofurans has been achieved. The spirocyclic products were generated in good to excellent yields with complete regiocontrol in a readily scalable procedure.
引用
收藏
页码：10920 / 10923
页数：4
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