Synthesis of next generation dual-responsive cross-linked nanoparticles and their application to anti-cancer drug delivery

被引:14
作者
Schwarzenboeck, Christina [1 ]
Nelson, Peter J. [2 ]
Huss, Ralf [3 ]
Rieger, Bernhard [1 ]
机构
[1] Tech Univ Munich, WACKER Lehrstuhl Makromol Chem, Lichtenbergstr 4, D-85748 Garching, Germany
[2] Univ Munich, Nephrol Zentrum & Arbeitsgrp Klin Biochem, Med Klin & Poliklin 4, Munich, Germany
[3] Definiens AG, Bernhard Wicki Str 5, D-80636 Munich, Germany
关键词
POLYMER THERAPEUTICS; CANCER-CHEMOTHERAPY; CELLULAR UPTAKE; CELLS; NANOCARRIERS; MICELLES; RELEASE; TUMOR; CYTOTOXICITY; DOXORUBICIN;
D O I
10.1039/c8nr04760j
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Rare earth metal-mediated group transfer polymerisation enables the synthesis of previously inaccessible block copolymers of 2-vinylpyridine, diethyl vinylphosphonate and the new diallyl vinylphosphonate monomer. This precision polymerisation and the selective cross-linking of allyl side groups via thiol-ene click chemistry leads to the formation of well-defined dual-responsive nanoparticles. We demonstrate that these next generation nanocarriers are pH- and temperature-responsive and are capable of efficiently delivering doxorubicin into the nucleus of cancer cells. High anti-cancer activity could be demonstrated via cytotoxicity tests on breast cancer (MCF-7) and cervical cancer (HeLa) cells. These results validate this modular synthesis route as an ideal platform for the development of sophisticated nanocarriers for future drug delivery applications.
引用
收藏
页码:16062 / 16068
页数:7
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