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Neuropsychological performance and regional cerebral blood flow in obsessive-compulsive disorder
被引:72
|作者:
Lacerda, ALT
Dalgalarrondo, P
Caetano, D
Haa, GL
Camargo, EE
Keshavan, MS
机构:
[1] Univ Pittsburgh, Sch Med, Western Psychiat Inst & Clin, Dept Psychiat, Pittsburgh, PA 15213 USA
[2] Univ Estadual Campinas, Sch Med Sci, Dept Med Psychol & Psychiat, Campinas, Brazil
[3] MIRECC, Vet Pittsburgh Healthcare Syst, Pittsburgh, PA USA
[4] Univ Estadual Campinas, Div Nucl Med, Dept Radiol, Fac Med Sci, Campinas, Brazil
来源:
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
|
2003年
/
27卷
/
04期
关键词:
frontal-subcortical circuits;
neuropsychology;
Rey-Osterrieth Complex Figure Test;
SPECT;
Trail Making Test;
Verbal Fluency Test;
Wisconsin Card Sorting Test;
D O I:
10.1016/S0278-5846(03)00076-9
中图分类号:
R74 [神经病学与精神病学];
学科分类号:
摘要:
Convergent findings from neuropsychological and neuroimaging studies have suggested that neural dysfunction in frontal-subcortical circuits may play a central role in the pathophysiology of obsessive-compulsive disorder (OCD). To further examine the relationship between these two sets of findings we investigated both neuropsychological functions and regional cerebral blood flow (rCBF) in a combined study. Fourteen unmedicated patients fulfilling DSM-IV criteria for OCD and 14 healthy controls matched for age, gender, handedness, and education were assessed on neuropsychological tests that included Trail Making Test (TMT), Rey Complex Figure Test (RCF) (copy and 5-min recall), Verbal Fluency Test (VFT), and Wisconsin Card Sorting Test (WCST). rCBF was studied with Tc-99 m-hexamethyl-propylencamine-oxime (HMPAO) single photon emission computed tomography (SPECT). Patients performed more poorly than controls (P<.05) on RCF (copy), VFT, and WCST (perseverative errors). Spearman's correlations indicated that severity of OCD correlated inversely with performance on the RCF (copy and recall scores) and positively with rCBF in the right thalamus. Positive correlations were observed between nonperseverative errors (WCST) and rCBF in frontal areas and anterior cingulate. Perseverative errors (WCST) correlated negatively with rCBF in the right thalamus. These findings are consistent with most previously published studies and suggest neural dysfunctions in the frontal-subcortical circuits probably more pronounced in the right hemisphere. They also extend the existing research, showing associations between deficits in cortical-subcortical circuitry and performance on neuropsychological tests of controlled attention and visuospatial functions. (C) 2003 Elsevier Science Inc. All rights reserved.
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页码:657 / 665
页数:9
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