Deamination and degradation of hydroxyl-containing dipeptides and tripeptides in the radiolysis of their aqueous solutions

被引：5

作者：

Shadyro, OI ^{[1
]}

Sosnovskaya, AA ^{[1
]}

Vrublevskaya, ON ^{[1
]}

机构：

[1] Belarusian State Univ, Minsk 220080, BELARUS

来源：

HIGH ENERGY CHEMISTRY | 2000年 / 34卷 / 05期

关键词：

D O I：

10.1007/BF02762680

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The effect of the presence of hydroxyl groups at the side chains of di- and tripeptides on the radiation-initiated deamination and main-chain cleavage was examined. It was found that the presence of hydroxyl groups is favorable to peptide main-chain degradation with the formation of amino acid amides. The deamination was intensified or inhibited depending on the positions of OH groups in the molecules of test compounds. As a rule, both deamination and main-chain degradation processes in oxygenated solutions of di- and tripeptides were inhibited because of oxidation of hydroxyl-containing groups in the starting substances.

引用

页码：290 / 294

页数：5

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