Mutations in AXIN2 gene as a risk factor for tooth agenesis and cancer: A review

被引：4

作者：

Hlouskova, Alena ^{[1
]}

Bielik, Peter ^{[1
]}

Bonczek, Ondrej ^{[1
]}

Balcar, Vladimir J. ^{[2
,3
]}

Sery, Omar ^{[1
,4
]}

机构：

[1] Masaryk Univ, Fac Sci, Dept Biochem, Lab Neurobiol & Mol Psychiat, Kotlarska 2, CS-61137 Brno, Czech Republic

[2] Univ Sydney, Sydney Med Sch, Sch Med Sci, Lab Neurochem,Bosch Inst, Sydney, NSW 2006, Australia

[3] Univ Sydney, Sydney Med Sch, Sch Med Sci, Discipline Anat & Histol, Sydney, NSW 2006, Australia

[4] Acad Sci Czech Republ, Inst Anim Physiol & Genet, Lab Neurobiol & Pathol Physiol, Brno, Czech Republic

来源：

NEUROENDOCRINOLOGY LETTERS | 2017年 / 38卷 / 03期

关键词：

hypodontia; oligodontia; Wnt signal pathway; beta-catenine; tankyrase; COLORECTAL-CANCER; SIGNALING PATHWAY; LUNG-CANCER; PAX9; GENE; POLYMORPHISMS; OLIGODONTIA; POPULATION; METAANALYSIS; CATENIN; SUSCEPTIBILITY;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

AXIN2 gene plays a crucial role in morphogenesis of craniofacial area and is essential for tooth development. AXIN2 gene is one of the most studied genes associated with tooth agenesis, the most common defect of dentition in humans. Polymorphic variants in AXIN2 gene are discussed in relation to the occurrence of the tooth agenesis but also as an indication of the risk of cancer. Mutations in AXIN2 gene were found in patients with colorectal or hepatocellular carcinoma, prostate cancer, ovarium or lung cancer. These findings support the hypothesis that missing teeth may be a significant marker for predisposition for cancer.

引用

页码：131 / 137

页数：7

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