Evaluation of the protective effects of curcumin and nanocurcumin against lung injury induced by sub-acute exposure to paraquat in rats

被引：37
|
作者：
Hosseini, Asieh [1 ]
Rasaie, Danyal [2 ]
Asl, Sara Soleymani [3 ]
Ahmadabadi, Amir Nili [4 ]
Ranjbar, Akram [4 ]
机构：
[1] Iran Univ Med Sci, Razi Drug Res Ctr, Tehran, Iran
[2] Hamadan Univ Med Sci, Student Res Comm, Hamadan, Iran
[3] Hamadan Univ Med Sci, Sch Med, Anat Dept, Hamadan, Iran
[4] Hamadan Univ Med Sci, Sch Pharm, Med Plants & Nat Prod Res Ctr, Dept Pharmacol & Toxicol, Hamadan 6517838678, Iran
来源：
TOXIN REVIEWS | 2021年 / 40卷 / 04期
关键词：
Curcumin; nanocurcumin; paraquat; oxidative stress; fibrosis; lung; INDUCED PULMONARY-FIBROSIS; OXIDATIVE STRESS; HEME OXYGENASE-1; INFLAMMATION; INHIBITION; MICE; ANTIOXIDANT;
D O I：
10.1080/15569543.2019.1675707
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
The aim of the current study is comparison the protective effects of curcumin and nanocurcumin against lung injury induced by sub-acute exposure with paraquat (PQ) through modulation of oxidative stress and gene expression. Oxidative stress biomarkers and genes expression were assessed by biochemical and RT-PCR analysis. Histopathological evaluation was performed by H&E staining. The results demonstrate that nanocurcumin to be superior to curcumin in protective effects on PQ-induced changes in mentioned factors. We found nanocurcumin had significantly more protective effect than curcumin to prevent the development of PQ-induced lung injury most probably via modulation of oxidative stress and gene expression.
引用
收藏
页码：1233 / 1241
页数：9
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