Trace elements are associated with urinary 8-hydroxy-2'-deoxyguanosine level: a case study of college students in Guangzhou, China

被引：38
作者：
Lu, Shaoyou [1 ]
Ren, Lu [2 ]
Fang, Jianzhang [2 ]
Ji, Jiajia [1 ]
Liu, Guihua [1 ]
Zhang, Jianqing [1 ]
Zhang, Huimin [1 ]
Luo, Ruorong [1 ]
Lin, Kai [1 ]
Fan, Ruifang [3 ]
机构：
[1] Shenzhen Ctr Dis Control & Prevent, Shenzhen 518055, Peoples R China
[2] S China Normal Univ, Sch Chem & Environm, Guangzhou 510006, Guangdong, Peoples R China
[3] S China Normal Univ, Sch Life Sci, Guangzhou Key Lab Subtrop Biodivers & Biomonitor, Guangzhou 510631, Guangdong, Peoples R China
来源：
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH | 2016年 / 23卷 / 09期
基金：
中国国家自然科学基金;
关键词：
Trace elements; 8-hydroxy-2 '-deoxyguanosine; Urine; Oxidative stress; OXIDATIVE DNA-DAMAGE; POLYCYCLIC AROMATIC-HYDROCARBONS; HEALTH-RISK ASSESSMENT; REFERENCE VALUES; FREE-RADICALS; HEAVY-METALS; ALUMINUM; STRESS; EXPOSURE; BLOOD;
D O I：
10.1007/s11356-016-6104-8
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Many trace heavy elements are carcinogenic and increase the incidence of cancer. However, a comprehensive study of the correlation between multiple trace elements and DNA oxidative damage is still lacking. The aim of this study is to investigate the relationships between the body burden of multiple trace elements and DNA oxidative stress in college students in Guangzhou, China. Seventeen trace elements in urine samples were determined by inductively coupled plasma-mass spectrometry (ICP-MS). Urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG), a biomarker of DNA oxidative stress, was also measured using liquid chromatography tandem mass spectrometer (LC-MS/MS). The concentrations of six essential elements including manganese (Mn), copper (Cu), nickel (Ni), selenium (Se), strontium (Sr), and molybdenum (Mo), and five non-essential elements including arsenic (As), cadmium (Cd), aluminum (Al), stibium (Sb), and thallium (Tl), were found to be significantly correlated with urinary 8-OHdG levels. Moreover, urinary levels of Ni, Se, Mo, As, Sr, and Tl were strongly significantly correlated with 8-OHdG (P < 0.01) concentration. Environmental exposure and dietary intake of these trace elements may play important roles in DNA oxidative damage in the population of Guangzhou, China.
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收藏
页码：8484 / 8491
页数：8
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