Building the ecosystem for pediatric neuro-oncology care in Pakistan: Results of a 7-year long twinning program between Canada and Pakistan

被引：17

作者：

Mushtaq, Naureen ^{[1
]}

Mustansir, Fatima ^{[1
]}

Minhas, Khurram ^{[1
]}

Usman, Sadia ^{[1
]}

Qureshi, Bilal Mazhar ^{[1
]}

Mubarak, Fatima ^{[1
]}

Bari, Ehsan ^{[1
]}

Enam, Syed Ather ^{[1
]}

Laghari, Altaf Ali ^{[1
]}

Javed, Gohar ^{[1
]}

Shamim, Shahzad ^{[1
]}

Darbar, Aneela ^{[1
]}

Abbasi, Ahmed Nadeem ^{[1
]}

Kirmani, Salman ^{[1
]}

Resham, Shahazadi ^{[1
]}

Bilal, Afia ^{[1
]}

Hamid, Syed Ahmer ^{[2
]}

Zia, Nida ^{[2
]}

Shaheen, Najma ^{[3
]}

Wali, Rabia ^{[3
]}

Ghafoor, Tariq ^{[4
]}

Imam, Uzma ^{[5
]}

Maaz, Ata Ur Rehman ^{[6
]}

Khan, Sara ^{[7
]}

Laperriere, Normand ^{[8
]}

Desbrandes, Francois ^{[9
]}

Dirks, Peter ^{[7
]}

Drake, James ^{[7
]}

Huang, Annie ^{[7
]}

Tabori, Uri ^{[7
]}

Hawkins, Cynthia ^{[7
]}

Bartels, Ute ^{[7
]}

Ramaswamy, Vijay ^{[7
]}

Bouffet, Eric ^{[7
]}

机构：

[1] Aga Khan Univ, Div Pediat Oncol, Dept Oncol, Karachi, Pakistan

[2] Indus Children Canc Hosp, Karachi, Pakistan

[3] Shaukat Khanum Mem Canc Hosp, Lahore, Pakistan

[4] Combined Mil Hosp, Rawalpindi, Pakistan

[5] Natl Inst Child Hlth, Karachi, Pakistan

[6] Sidra Hosp, Doha, Qatar

[7] Hosp Sick Children, Toronto, ON, Canada

[8] Princess Margaret Canc Ctr, Toronto, ON, Canada

[9] MCM Program Sanofi Espoir Aventis Fdn, Paris, France

来源：

PEDIATRIC BLOOD & CANCER | 2022年 / 69卷 / 09期

关键词：

LMIC; pediatric neuro-oncology; twinning; BRAIN-TUMORS; CANCER; TELEMEDICINE; CHILDREN; IMPLEMENTATION; MANAGEMENT; THERAPY; COUNTRY; HEALTH; IMPACT;

D O I：

10.1002/pbc.29726

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background Low- and middle-income countries sustain the majority of pediatric cancer burden, with significantly poorer survival rates compared to high-income countries. Collaboration between institutions in low- and middle-income countries and high-income countries is one of the ways to improve cancer outcomes. Methods Patient characteristics and effects of a pediatric neuro-oncology twinning program between the Hospital for Sick Children in Toronto, Canada and several hospitals in Karachi, Pakistan over 7 years are described in this article. Results A total of 460 patients were included in the study. The most common primary central nervous system tumors were low-grade gliomas (26.7%), followed by medulloblastomas (18%), high-grade gliomas (15%), ependymomas (11%), and craniopharyngiomas (11.7%). Changes to the proposed management plans were made in consultation with expert physicians from the Hospital for Sick Children in Toronto, Canada. On average, 24% of the discussed cases required a change in the original management plan over the course of the twinning program. However, a decreasing trend in change in management plans was observed, from 36% during the first 3.5 years to 16% in the last 3 years. This program also led to the launch of a national pediatric neuro-oncology telemedicine program in Pakistan. Conclusions Multidisciplinary and collaborative efforts by experts from across the world have aided in the correct diagnosis and treatment of children with brain tumors and helped establish local treatment protocols. This experience may be a model for other low- and middle-income countries that are planning on creating similar programs.

引用

页数：9