The role of complement and Toll-like receptors in organ transplantation

被引：16
|
作者：
Lin, Tao
Zhou, Wuding
Sacks, Steven H. [1 ]
机构：
[1] Guys Hosp, Kings Coll London Sch Med, Dept Nephrol & Transplantat, London SE1 9RT, England
[2] Kings Coll Hosp London, Kings Coll London Sch Med, Dept Nephrol & Transplantat, London, England
[3] St Thomas Hosp, Kings Coll London Sch Med, Dept Nephrol & Transplantat, London, England
[4] Sichuan Univ, W China Hosp, Dept Urol, Chengdu 610064, Peoples R China
来源：
TRANSPLANT INTERNATIONAL | 2007年 / 20卷 / 06期
基金：
英国医学研究理事会; 英国惠康基金;
关键词：
complement immunity; natural Toll-like receptor transplantation; ISCHEMIA-REPERFUSION INJURY; DECAY-ACCELERATING FACTOR; ACUTE ALLOGRAFT-REJECTION; ACUTE-RENAL-FAILURE; ADAPTIVE IMMUNE-RESPONSES; DENDRITIC CELL MATURATION; TH2 EFFECTOR FUNCTIONS; CD8(+) T-CELLS; ISCHEMIA/REPERFUSION INJURY; COMPONENT C3;
D O I：
10.1111/j.1432-2277.2006.00448.x
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
The innate immune system not only participates in host defence but also contributes to the control of adaptive immune responses. Complement and Toll-like receptors (TLR) are key components of innate immunity. Emerging evidence suggests their activation is involved in all major aspects of transplantation. This paper reviews the current understanding of how the complement and TLR on impact transplant injury.
引用
收藏
页码：481 / 489
页数：9
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