Hantavirus hemorrhagic fever with renal syndrome (HFRS) is a zoonotic disease characterized by acute onset, fever, malaise, and back pain. As the disease progresses, hemorrhagic disturbances and kidney dysfunctions predominate. The examination of tissue collected postmortem supports the premise that virus replication is not responsible for this pathology; therefore, it is widely believed that virus-induced immune responses lead to the clinical manifestations associated with HFRS. The overproduction of inflammatory cytokines is commonly reported in subjects with HFRS and has given rise to the hypothesis that a so-called "cytokine storm" may play a pivotal role in the pathogenesis of this disease. Currently, supportive care remains the only effective treatment for HFRS. Our data show that serum levels of interferon (IFN)-gamma, interleukin (IL)-10, CCL2, and IL-12 are upregulated in HFRS cases when compared to healthy controls and the level of upregulation is dependent on the phase and severity of the disease. Furthermore, we observed an association between the mild form of the disease and elevated serum levels of IFN-gamma and IL-12. Collectively, these observations suggest that the administration of exogenous IFN-gamma and IL-12 may provide antiviral benefits for the treatment of HFRS and, thus, warrants further investigations.
机构:
Univ Louisville, Ctr Predict Med Biodefense & Emerging Infect Dis, Louisville, KY 40222 USA
Univ Louisville, Dept Microbiol & Immunol, Louisville, KY 40222 USAUniv Louisville, Ctr Predict Med Biodefense & Emerging Infect Dis, Louisville, KY 40222 USA
Jonsson, Colleen B.
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Moraes Figueiredo, Luiz Tadeu
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机构:
Univ Sao Paulo, Sch Med, Virol Res Ctr, BR-14049 Ribeirao Preto, SP, BrazilUniv Louisville, Ctr Predict Med Biodefense & Emerging Infect Dis, Louisville, KY 40222 USA
Moraes Figueiredo, Luiz Tadeu
;
Vapalahti, Olli
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机构:
Univ Helsinki, HUSLAB, Haartman Inst, Dept Virol, Helsinki, Finland
Univ Helsinki, HUSLAB, Dept Vet Basic Sci, Helsinki, FinlandUniv Louisville, Ctr Predict Med Biodefense & Emerging Infect Dis, Louisville, KY 40222 USA
机构:
Univ Louisville, Ctr Predict Med Biodefense & Emerging Infect Dis, Louisville, KY 40222 USA
Univ Louisville, Dept Microbiol & Immunol, Louisville, KY 40222 USAUniv Louisville, Ctr Predict Med Biodefense & Emerging Infect Dis, Louisville, KY 40222 USA
Jonsson, Colleen B.
;
Moraes Figueiredo, Luiz Tadeu
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Sch Med, Virol Res Ctr, BR-14049 Ribeirao Preto, SP, BrazilUniv Louisville, Ctr Predict Med Biodefense & Emerging Infect Dis, Louisville, KY 40222 USA
Moraes Figueiredo, Luiz Tadeu
;
Vapalahti, Olli
论文数: 0引用数: 0
h-index: 0
机构:
Univ Helsinki, HUSLAB, Haartman Inst, Dept Virol, Helsinki, Finland
Univ Helsinki, HUSLAB, Dept Vet Basic Sci, Helsinki, FinlandUniv Louisville, Ctr Predict Med Biodefense & Emerging Infect Dis, Louisville, KY 40222 USA