Upregulation of IFN-γ and IL-12 is associated with a milder form of hantavirus hemorrhagic fever with renal syndrome

被引:24
作者
Khaiboullina, S. F. [1 ,2 ]
Martynova, E. V. [3 ]
Khamidullina, Z. L. [4 ]
Lapteva, E. V. [4 ]
Nikolaeva, I. V. [3 ]
Anokhin, V. V. [3 ]
Lombardi, V. C. [1 ,2 ]
Rizvanov, A. A. [2 ]
机构
[1] Univ Nevada, Sch Med, Dept Biochem & Mol Biol, WPI, Reno, NV 89557 USA
[2] Kazan Volga Reg Fed Univ, Inst Fundamental Med & Biol, Kazan, Republic Of Tat, Russia
[3] Kazan State Med Univ, Kazan 420012, Republic Of Tat, Russia
[4] Agafonov Republican Clin Hosp Infect Dis, Kazan 420140, Republic Of Tat, Russia
关键词
TUMOR-NECROSIS-FACTOR; CHEMOATTRACTANT PROTEIN-1 MCP-1; VIRUS NUCLEOCAPSID PROTEIN; ADAPTIVE IMMUNE-RESPONSES; NEPHROPATHIA-EPIDEMICA; PUUMALA-HANTAVIRUS; T-CELLS; INTERFERON-GAMMA; CLINICAL CHARACTERISTICS; ACUTE DISEASE;
D O I
10.1007/s10096-014-2176-x
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Hantavirus hemorrhagic fever with renal syndrome (HFRS) is a zoonotic disease characterized by acute onset, fever, malaise, and back pain. As the disease progresses, hemorrhagic disturbances and kidney dysfunctions predominate. The examination of tissue collected postmortem supports the premise that virus replication is not responsible for this pathology; therefore, it is widely believed that virus-induced immune responses lead to the clinical manifestations associated with HFRS. The overproduction of inflammatory cytokines is commonly reported in subjects with HFRS and has given rise to the hypothesis that a so-called "cytokine storm" may play a pivotal role in the pathogenesis of this disease. Currently, supportive care remains the only effective treatment for HFRS. Our data show that serum levels of interferon (IFN)-gamma, interleukin (IL)-10, CCL2, and IL-12 are upregulated in HFRS cases when compared to healthy controls and the level of upregulation is dependent on the phase and severity of the disease. Furthermore, we observed an association between the mild form of the disease and elevated serum levels of IFN-gamma and IL-12. Collectively, these observations suggest that the administration of exogenous IFN-gamma and IL-12 may provide antiviral benefits for the treatment of HFRS and, thus, warrants further investigations.
引用
收藏
页码:2149 / 2156
页数:8
相关论文
共 65 条
[11]   HANTAVIRUS PULMONARY SYNDROME - A CLINICAL DESCRIPTION OF 17 PATIENTS WITH A NEWLY RECOGNIZED DISEASE [J].
DUCHIN, JS ;
KOSTER, FT ;
PETERS, CJ ;
SIMPSON, GL ;
TEMPEST, B ;
ZAKI, SR ;
KSIAZEK, TG ;
ROLLIN, PE ;
NICHOL, S ;
UMLAND, ET ;
MOOLENAAR, RL ;
REEF, SE ;
NOLTE, KB ;
GALLAHER, MM ;
BUTLER, JC ;
BREIMAN, RF ;
BURKHART, M ;
KALISHMAN, N ;
VOORHEES, R ;
VOORHEES, J ;
SAMUEL, M ;
TANUZ, M ;
HUGHES, L ;
WICTOR, S ;
OTY, G ;
NIMS, L ;
CASTLE, S ;
BRYT, B ;
SEWELL, CM ;
REYNOLDS, P ;
BROWN, T ;
SANDS, L ;
KOMATSU, K ;
KIOSKI, C ;
FLEMING, K ;
DOLL, J ;
LEVY, C ;
FINK, TM ;
MURPHY, P ;
ENGLAND, B ;
SMOLINSKI, M ;
ERICKSON, B ;
SLANTA, W ;
GELLERT, G ;
SCHILLAM, P ;
HOFFMAN, RE ;
LANSER, S ;
NICHOLS, C ;
HUBBARDPOURIER, L ;
CHEEK, J .
NEW ENGLAND JOURNAL OF MEDICINE, 1994, 330 (14) :949-955
[12]   Determination of urine tumor necrosis factor, IL-6, IL-8, and serum IL-6 in patients with hemorrhagic fever with renal syndrome [J].
Fan, Wanhu ;
Liu, Xiaojing ;
Yue, Jinsheng .
BRAZILIAN JOURNAL OF INFECTIOUS DISEASES, 2012, 16 (06) :527-530
[13]   Genetic Diversity and Geographic Distribution of Hantaviruses in Russia [J].
Garanina, S. B. ;
Platonov, A. E. ;
Zhuravlev, V. I. ;
Murashkina, A. N. ;
Yakimenko, V. V. ;
Korneev, A. G. ;
Shipulin, G. A. .
ZOONOSES AND PUBLIC HEALTH, 2009, 56 (6-7) :297-309
[14]   RECOMBINANT TUMOR NECROSIS FACTOR INCREASES PULMONARY VASCULAR-PERMEABILITY INDEPENDENT OF NEUTROPHILS [J].
HORVATH, CJ ;
FERRO, TJ ;
JESMOK, G ;
MALIK, AB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (23) :9219-9223
[15]   HEMORRHAGIC-FEVER WITH RENAL SYNDROME - RELATIONSHIP BETWEEN PATHOGENESIS AND CELLULAR-IMMUNITY [J].
HUANG, CS ;
JIN, BQ ;
WANG, MX ;
LI, ES ;
SUN, C .
JOURNAL OF INFECTIOUS DISEASES, 1994, 169 (04) :868-870
[16]   PROSPECTIVE, DOUBLE-BLIND, CONCURRENT, PLACEBO-CONTROLLED CLINICAL-TRIAL OF INTRAVENOUS RIBAVIRIN THERAPY OF HEMORRHAGIC-FEVER WITH RENAL SYNDROME [J].
HUGGINS, JW ;
HSIANG, CM ;
COSGRIFF, TM ;
GUANG, MY ;
SMITH, JI ;
WU, ZO ;
LEDUC, JW ;
ZHENG, ZM ;
MEEGAN, JM ;
WANG, QN ;
OLAND, DD ;
GUI, XE ;
GIBBS, PH ;
YUAN, GH ;
ZHANG, TM .
JOURNAL OF INFECTIOUS DISEASES, 1991, 164 (06) :1119-1127
[17]   A Global Perspective on Hantavirus Ecology, Epidemiology, and Disease [J].
Jonsson, Colleen B. ;
Moraes Figueiredo, Luiz Tadeu ;
Vapalahti, Olli .
CLINICAL MICROBIOLOGY REVIEWS, 2010, 23 (02) :412-+
[18]   Effects of tumor necrosis factor alpha on Sin Nombre virus infection in vitro [J].
Khaiboullina, SF ;
Netski, DM ;
Krumpe, P ;
St Jeor, SC .
JOURNAL OF VIROLOGY, 2000, 74 (24) :11966-11971
[19]   Viral load and immune response dynamics in patients with haemorrhagic fever with renal syndrome [J].
Korva, M. ;
Saksida, A. ;
Kejzar, N. ;
Schmaljohn, C. ;
Avsic-Zupanc, T. .
CLINICAL MICROBIOLOGY AND INFECTION, 2013, 19 (08) :E358-E366
[20]   Serum TNF-α, sTNFR1, IL-6, IL-8 and IL-10 levels in hemorrhagic fever with renal syndrome [J].
Kyriakidis, Ioannis ;
Papa, Anna .
VIRUS RESEARCH, 2013, 175 (01) :91-94