Prognostic significance of p-STAT3 in patients with bulky cervical carcinoma undergoing neoadjuvant chemotherapy

被引：15

作者：

Choi, Chel Hun ^{[1
]}

Song, Sang Yong ^{[2
]}

Kang, Heeseok ^{[1
]}

Lee, Yoo-Young ^{[1
]}

Kim, Chul-Jung ^{[1
]}

Lee, Jeong-Won ^{[1
]}

Kim, Tae-Joong ^{[1
]}

Kim, Byoung-Gie ^{[1
]}

Lee, Je-Ho ^{[1
]}

Bae, Duk-Soo ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Sch Med, Dept Obstet & Gynecol, Samsung Med Ctr, Seoul 135710, South Korea

[2] Sungkyunkwan Univ, Sch Med, Dept Pathol, Samsung Med Ctr, Seoul 135710, South Korea

来源：

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH | 2010年 / 36卷 / 02期

关键词：

bulky cervical carcinoma; immunohistochemistry; p-STAT3; SQUAMOUS-CELL CARCINOMA; CONSTITUTIVE ACTIVATION; MOLECULAR TARGETS; CANCER CELLS; TRANSCRIPTIONAL CONTROL; SIGNAL TRANSDUCERS; GASTRIC-CANCER; PHASE-II; STAT3; EXPRESSION;

D O I：

10.1111/j.1447-0756.2009.01131.x

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Aim: To better predict treatment responses for managing bulky cervical carcinoma with neoadjuvant chemotherapy (NAC). Methods: The expression of p-STAT3 was analyzed by immunohistochemistry using paraffin-embedded pretreatment cervical biopsy tissues. The study included 29 patients with bulky IB to IIA cervical squamous cell carcinoma treated with NAC. Results: Twenty (69.0%) of 29 patients were scored as p-STAT3-positive. Pathological response to chemotherapy (complete response or residual tumor with less than 3 mm stromal invasion) was observed in eight patients (27.6%). The p-STAT3-positive patients had a longer disease-free survival compared to p-STAT3-negative patients (P = 0.03), though they had more frequent clinical nodal involvement (P = 0.046). Conclusion: Pretreatment assessment of p-STAT3 expression may provide additional information for the identification of patients with cervical cancer who have a favorable prognosis.

引用

页码：304 / 310

页数：7

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