V Spanish Consensus Conference on Helicobacter pylori infection treatment

被引:5
作者
Gisbert, Javier P. [1 ]
Alcedo, Javier [2 ]
Amador, Javier [3 ]
Bujanda, Luis [4 ]
Calvet, Xavier [5 ]
Castro-Fernandez, Manuel [6 ]
Fernandez-Salazar, Luis [7 ]
Gene, Emili [8 ]
Lanas, Angel [9 ]
Lucendo, Alfredo J. [10 ]
Molina-Infante, Javier [11 ]
Nyssen, Olga P.
Perez-Aisa, A. [12 ]
Puig, Ignasi [13 ]
机构
[1] Univ Autonoma Madrid UAM, Hosp Univ Princesa, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Serv Aparato Digest, Madrid, Spain
[2] Hosp Univ Miguel Servet, Serv Aparato Digest, Inst Invest Sanitaria Aragon IIS Aragon, Zaragoza, Spain
[3] SERMAS, Ctr Salud Angeles, Direcc Asistencial Ctr, Med Familia, Madrid, Spain
[4] Univ Pais Vasco UPV, Hosp Donostia, Serv Aparato Digest, Inst Biodonostia, San Sebastian, Spain
[5] Univ Autonoma Barcelona, Hosp Parc Tauli, Serv Aparato Digest, CIBEREHD, Sabadell, Barcelona, Spain
[6] Hosp Univ Valme, Serv Aparato Digest, CIBEREHD, Seville, Spain
[7] Univ Valladolid, Hosp Clin Univ Valladolid, Serv Aparato Digest, Gerencia Reg Salud SACYL, Valladolid, Spain
[8] Univ Int Catalunya, Hosp Parc Tauli Sabadell, Serv Urgencias, CIBEREHD, Barcelona, Spain
[9] CIBEREHD, Hosp Clin Univ Zaragoza, Serv Aparato Digest, Inst Invest Sanitaria Aragon IIS Aragon, Zaragoza, Spain
[10] CIBEREHD, Hosp Gen Tomelloso, Serv Aparato Digest, Ciudad Real, Spain
[11] CIBEREHD, Hosp Univ Caceres, Serv Aparato Digest, Caceres, Spain
[12] Agencia Sanitaria Costa Sol, Serv Aparato Digest, Marbella, Malaga, Spain
[13] Univ Vic, Univ Cent Catalunya UVicUCC, Serv Aparato Digest, Althaia Xarxa Assistencial Univ Manresa, Manresa, Barcelona, Spain
来源
GASTROENTEROLOGIA Y HEPATOLOGIA | 2022年 / 45卷 / 05期
关键词
Bismuth; Clarithromycin; Helicobacter pylori; Proton pump inhibitor; Levofloxacin; Metronidazole; Omeprazole; Tetracycline; NON-BISMUTH QUADRUPLE; STANDARD TRIPLE THERAPY; 3RD-LINE RESCUE THERAPY; PROTON PUMP INHIBITOR; MAASTRICHT-III CONSENSUS; NON-ERADICATION THERAPY; BLEEDING PEPTIC-ULCER; DUODENAL-ULCER; CONCOMITANT THERAPY; SEQUENTIAL THERAPY;
D O I
10.1016/j.gastrohep.2021.07.011
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Helicobacter pylori infection is very common in the Spanish population and represents the main cause of chronic gastritis, peptic ulcer, and gastric cancer. The last iteration of Spanish consensus guidelines on H. pylori infection was conducted in 2016. Recent changes in therapeutic schemes along with increasing supporting evidence were key for developing the V Spanish Consensus Conference (May 2021). Fourteen experts performed a systematic review of the scientific evidence and developed a series of recommendations that were subjected to an anonymous Delphi process of iterative voting. Scientific evidence and the strength of the recommendation were classified using GRADE guidelines. An eradication therapy, when prescribed empirically, is considered acceptable when it reliably achieves, or preferably surpass, 90% cure rates. Currently, only quadruple therapies (with or without bismuth) and generally lasting 14 days, accomplish this goal in first-and second-line therapies. A non-bismuth quadruple concomitant regimen (proton pump inhibitor, clarithromycin, amoxicillin, and metronidazole) or a quadruple bismuth-based combination (proton pump inhibitor, bismuth, tetracycline, and metronidazole), are recommended as first-line regimens. Rescue therapies after eradication failure and management of H. pylori infection in peptic ulcer disease were also reviewed. (c) 2021 Elsevier Espana, S.L.U. All rights reserved.
引用
收藏
页码:392 / 417
页数:26
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