General and practical intramolecular decarbonylative coupling of thioesters via palladium catalysis

被引：25

作者：

Cao, Han ^{[1
]}

Liu, Xuejing ^{[1
]}

Bie, Fusheng ^{[1
]}

Shi, Yijun ^{[1
]}

Han, Ying ^{[1
]}

Yan, Peng ^{[1
]}

Szostak, Michal ^{[2
]}

Liu, Chengwei ^{[2
]}

机构：

[1] Zaozhuang Univ, Shandong Lunan Coal Chem Res Inst Engn & Technol, 1 Beian Rd, Zaozhuang 277160, Shandong, Peoples R China

[2] Rutgers State Univ, Dept Chem, 73 Warren St, Newark, NJ 07102 USA

来源：

ORGANIC CHEMISTRY FRONTIERS | 2021年 / 8卷 / 07期

关键词：

D O I：

10.1039/d0qo01576h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report a general and practical palladium-catalyzed intramolecular decarbonylative coupling of thioesters via C-S bond cleavage, decarbonylation and C-S bond reformation. This robust approach shows excellent functional group tolerance and broad substrate scope using a commercially available, cheap, and practical Pd(OAc)(2) catalyst and phosphine ligands. This strategy operates under base-free conditions. The catalytic system represents the simplest method for intramolecular decarbonylation of thioesters by palladium catalysis reported to date. This versatile protocol is readily performed on a gram scale and applied in late-stage drug derivatization.

引用

页码：1587 / 1592

页数：6

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