Short Report: Elevation of Serum B-Cell Activating Factor Levels During Visceral Leishmaniasis

被引：17

作者：

Goto, Yasuyuki ^{[1
]}

Omachi, Satoko ^{[1
]}

Sanjoba, Chizu ^{[1
]}

Matsumoto, Yoshitsugu ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Agr & Life Sci, Dept Anim Resource Sci, Lab Mol Immunol, Tokyo 1138657, Japan

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2014年 / 91卷 / 05期

基金：

日本科学技术振兴机构; 日本学术振兴会;

关键词：

SYSTEMIC-LUPUS-ERYTHEMATOSUS; TANDEM REPEAT PROTEINS; INDIAN KALA-AZAR; LYMPHOCYTE STIMULATOR; BAFF; DISORDERS; INFECTION; MALARIA;

D O I：

10.4269/ajtmh.14-0260

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Elevation of serum B-cell activating factor (BAFF) is one of the characteristics of immunological disorders, including autoimmunity, but the levels of BAFF in infectious diseases have not been studied well. Here, we showed the elevation of serum BAFF in patients with visceral leishmaniasis (VL). The mean serum BAFF value in VL patients (4.65 ng/mL) was 4.3 times higher than that of healthy controls (1.08 ng/mL), and 90% of VL patients showed serum BAFF above the cutoff that was calculated as the mean + 3 SDs of the controls. This report is the first on elevation of serum BAFF during VL.

引用

页码：912 / 914

页数：3

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