Hyperforin modifies neuronal membrane properties in vivo

被引：32
作者：
Eckert, GP
Keller, JH
Jourdan, C
Karas, M
Volmer, DA
Schubert-Zsilavecz, M
Müller, WE
机构：
[1] Goethe Univ Frankfurt, Inst Pharmacol, Bioctr N260, D-60439 Frankfurt, Germany
[2] Goethe Univ Frankfurt, Inst Pharmaceut Chem, D-60439 Frankfurt, Germany
[3] Natl Res Council Canada, Inst Marine Biosci, Halifax, NS B3H 3Z1, Canada
来源：
NEUROSCIENCE LETTERS | 2004年 / 367卷 / 02期
关键词：
Hypericum perforatum; St. John's Wort; hyperforin; brain; membrane; fluidity; HPLC; MS;
D O I：
10.1016/j.neulet.2004.04.053
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Hyperforin, the major active constituent of St. John Wort (SJW) extract, affects several neurotransmitter systems in the brain putatively by modulation of the physical state of neuronal membranes. Accordingly, we tested the effects of SJW extract and of hyperforin on the properties of murine brain membrane fluidity. Oral administration of SJW extract and of hyperforin sodium salt results in significant hyperforin brain levels. Treatment of mice with hyperforin leads to decreased annular- and bulk fluidity and increased acyl-chain flexibility of brain membranes. All hyperforin related changs of membrane properties were significantly correlated with the corresponding hyperforin brain levels. Our data emphasises a membrane interaction of hyperforin that possibly contributes to its pharmacological effects. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：139 / 143
页数：5
相关论文
共 21 条
[1]   Oral bioavailability of hyperforin from Hypericum extracts in rats and human volunteers [J].
Biber, A ;
Fischer, H ;
Romer, A ;
Chatterjee, SS .
PHARMACOPSYCHIATRY, 1998, 31 :36-43
[2]   Role of hyperforin in the antidepressant-like activity of Hypericum perforatum extracts [J].
Cervo, L ;
Rozio, M ;
Ekalle-Soppo, CB ;
Guiso, G ;
Morazzoni, P ;
Caccia, S .
PSYCHOPHARMACOLOGY, 2002, 164 (04) :423-428
[3]   Hyperforin attenuates various ionic conductance mechanisms in the isolated hippocampal neurons of rat [J].
Chatterjee, S ;
Filippov, V ;
Lishko, P ;
Maximyuk, O ;
Nöldner, M ;
Krishtal, O .
LIFE SCIENCES, 1999, 65 (22) :2395-2405
[4]   FLOW-MEDIATED ENDOTHELIAL MECHANOTRANSDUCTION [J].
DAVIES, PF .
PHYSIOLOGICAL REVIEWS, 1995, 75 (03) :519-560
[5]  
Eckert GP, 2001, PHARMACOPSYCHIATRY, V34, pS22, DOI 10.1055/s-2001-15461
[6]  
FEISST C, BIOCH PHARM, V67, P15310
[7]   Plasma pharmacokinetics and cerebrospinal fluid penetration of hypericin in nonhuman primates [J].
Fox, E ;
Murphy, RF ;
McCully, CL ;
Adamson, PC .
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2001, 47 (01) :41-44
[8]   Modulation of GTPase activity of G proteins by fluid shear stress and phospholipid composition [J].
Gudi, S ;
Nolan, JP ;
Frangos, JA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (05) :2515-2519
[9]   Location of diphenylhexatriene (DPH) and its derivatives within membranes: Comparison of different fluorescence quenching analyses of membrane depth [J].
Kaiser, RD ;
London, E .
BIOCHEMISTRY, 1998, 37 (22) :8180-8190
[10]   Determination of hyperforin in mouse brain by high-performance liquid chromatography/tandem mass spectrometry [J].
Keller, JH ;
Karas, M ;
Müller, WE ;
Volmer, DA ;
Eckert, GP ;
Tawab, MA ;
Blume, HH ;
Dingermann, T ;
Schubert-Zsilavecz, M .
ANALYTICAL CHEMISTRY, 2003, 75 (22) :6084-6088
123