Active compounds and molecular targets of Chinese herbal medicine for neurogenesis in stroke treatment: Implication for cross talk between Traditional Chinese Medicine and Biomedical Sciences

被引:5
作者
Chen, Xi [1 ,2 ,3 ]
Chen, Han-Sen [1 ]
Peng, Cheng [4 ,5 ]
Shen, Jian-Gang [1 ,2 ]
机构
[1] Univ Hong Kong, Sch Chinese Med, LKS Fac Med, Hong Kong, Peoples R China
[2] Peoples Hosp Bao An, Dept Core Facil, Chengdu, Peoples R China
[3] Southern Med Univ, Peoples Hosp Shenzhen 8, Dept Core Facil, Affiliated Baoan Hosp, Chengdu, Peoples R China
[4] Chengdu Univ Tradit Chinese Med, Coll Med Technol, State Key Lab Breeding Base Systemat Res Dev & Ut, Sichuan Prov & Minist Sci & Technol, Chengdu, Peoples R China
[5] Chengdu Univ Tradit Chinese Med, Sch Pharm, State Key Lab Breeding Base Systemat Res Dev & Ut, Sichuan Prov & Minist Sci & Technol, Chengdu, Peoples R China
关键词
Chinese herbal medicine; neurogenesis; stroke;
D O I
10.4103/wjtcm.wjtcm_14_19
中图分类号
R [医药、卫生];
学科分类号
10 ;
摘要
Neural stem/progenitor cells (NSCs) could be attractive therapeutic targets for promoting adult neurogenesis, brain plasticity, and repair in stroke and neurodegenerative diseases, raising great potentials for regeneration therapy. In adult ischemic brains, NSCs have limited capacities of growth, differentiation, and generating new neurons for repairing the damaged central nervous system. However, the spontaneous brain repair seems to be insufficient to recover neurological deficits in most stroke cases. To overcome those problems, pharmacological manipulations targeting on endogenous NSCs or transplanted stem cells could be a promoting strategy for regeneration therapy. Chinese herbal medicine has great potentials for developing novel therapeutic strategies for adult neurogenesis and brain repair in poststroke treatment. Chinese herbal medicine has a long history for poststroke treatment. Recent studies create great opportunity for drug discovery for promoting neurogenesis and improving the recovery of neurological functions in poststroke treatment. Many active compounds or extracts from medicinal herbs have shown promising effects on regulating proliferation, self-renewal and differentiation of NSCs, and promoting neural network formation as well as neurological functional recovery with in vitro and in vivo experimental evidence. Therefore, targeting neural stem/progenitor cells can be an important opportunity for the studies of Traditional Chinese Medicine in regeneration medicine. Due to the complex interactions of herbal ingredients in network regulation, huge challenge remains to be resolved for further study.
引用
收藏
页码:104 / 115
页数:12
相关论文
共 77 条
  • [1] Neurogenesis in adult subventricular zone
    Alvarez-Buylla, A
    García-Verdugo, JM
    [J]. JOURNAL OF NEUROSCIENCE, 2002, 22 (03) : 629 - 634
  • [2] Balami JS, 2013, CNS NEUROL DISORD-DR, V12, P155
  • [3] Gender and Stroke Symptoms: A Review of the Current Literature
    Beal, Claudia C.
    [J]. JOURNAL OF NEUROSCIENCE NURSING, 2010, 42 (02) : 80 - 87
  • [4] Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus
    Cameron, HA
    McKay, RDG
    [J]. JOURNAL OF COMPARATIVE NEUROLOGY, 2001, 435 (04) : 406 - 417
  • [5] One-Compound-Multi-Target: Combination Prospect of Natural Compounds with Thrombolytic Therapy in Acute Ischemic Stroke
    Chen, Han-Sen
    Qi, Su-Hua
    Shen, Jian-Gang
    [J]. CURRENT NEUROPHARMACOLOGY, 2017, 15 (01) : 134 - 156
  • [6] Baicalin Attenuates Blood-Brain Barrier Disruption and Hemorrhagic Transformation and Improves Neurological Outcome in Ischemic Stroke Rats with Delayed t-PA Treatment: Involvement of ONOO--MMP-9 Pathway
    Chen, Hansen
    Guan, Binghe
    Chen, Xi
    Chen, Xingmiao
    Li, Caiming
    Qiu, Jinhua
    Yang, Dan
    Liu, Ke Jian
    Qi, Suhua
    Shen, Jiangang
    [J]. TRANSLATIONAL STROKE RESEARCH, 2018, 9 (05) : 515 - 529
  • [7] Astragaloside VI Promotes Neural Stem Cell Proliferation and Enhances Neurological Function Recovery in Transient Cerebral Ischemic Injuryvia Activating EGFR/MAPK Signaling Cascades
    Chen, Xi
    Wu, Hao
    Chen, Hansen
    Wang, Qi
    Xie, Xue-jiao
    Shen, Jiangang
    [J]. MOLECULAR NEUROBIOLOGY, 2019, 56 (04) : 3053 - 3067
  • [8] Peroxynitrite enhances self-renewal, proliferation and neuronal differentiation of neural stem/progenitor cells through activating HIF-1α and Wnt/β-catenin signaling pathway
    Chen, Xingmiao
    Zhou, Binghua
    Yan, Tingting
    Wu, Hao
    Feng, Jinghan
    Chen, Hansen
    Gao, Chong
    Peng, Tao
    Yang, Dan
    Shen, Jiangang
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 2018, 117 : 158 - 167
  • [9] Tenuigenin Promotes Proliferation and Differentiation of Hippocampal Neural Stem Cells
    Chen, Yujing
    Huang, Xiaobo
    Chen, Wenqiang
    Wang, Ningqun
    Li, Lin
    [J]. NEUROCHEMICAL RESEARCH, 2012, 37 (04) : 771 - 777
  • [10] Global and regional burden of stroke during 1990-2010: findings from the Global Burden of Disease Study 2010
    Feigin, Valery L.
    Forouzanfar, Mohammad H.
    Krishnamurthi, Rita
    Mensah, George A.
    Connor, Myles
    Bennett, Derrick A.
    Moran, Andrew E.
    Sacco, Ralph L.
    Anderson, Laurie
    Truelsen, Thomas
    O'Donnell, Martin
    Venketasubramanian, Narayanaswamy
    Barker-Collo, Suzanne
    Lawes, Carlene M. M.
    Wang, Wenzhi
    Shinohara, Yukito
    Witt, Emma
    Ezzati, Majid
    Naghavi, Mohsen
    Murray, Christopher
    [J]. LANCET, 2014, 383 (9913) : 245 - 255