Carcinoma-associated fibroblasts: orchestrating the composition of malignancy

被引：581

作者：

Gascard, Philippe ^{[1
]}

Tlsty, Thea D. ^{[1
,2
]}

机构：

[1] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94143 USA

来源：

GENES & DEVELOPMENT | 2016年 / 30卷 / 09期

基金：

美国国家卫生研究院;

关键词：

carcinoma-associated fibroblasts; CAF; microenvironment; field cancerization; stromal-epithelial interactions; CAF targeted therapies; CANCER-ASSOCIATED FIBROBLASTS; MARROW-DERIVED MYOFIBROBLASTS; SOMATIC GENETIC ALTERATIONS; PROMOTE TUMOR-GROWTH; BREAST-CANCER; EPITHELIAL-CELLS; PROSTATE-CANCER; IN-SITU; PANCREATIC-CANCER; DRUG-RESISTANCE;

D O I：

10.1101/gad.279737.116

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The tumor stroma is no longer seen solely as physical support for mutated epithelial cells but as an important modulator and even a driver of tumorigenicity. Within the tumor stromal milieu, heterogeneous populations of fibroblast-like cells, collectively termed carcinoma-associated fibroblasts (CAFs), are key players in the multicellular, stromal-dependent alterations that contribute to malignant initiation and progression. This review focuses on novel insights into the contributions of CAFs to disease progression, emergent events leading to the generation of CAFs, identification of CAF-specific biomarkers predictive of disease outcome, and recent therapeutic approaches aimed at blunting or reverting detrimental protumorigenic phenotypes associated with CAFs.

引用

页码：1002 / 1019

页数：18

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