A fully electronic DNA sensor with 128 positions and in-pixel A/D conversion

被引：137

作者：

Schienle, M ^{[1
]}

Paulus, C ^{[1
]}

Frey, A ^{[1
]}

Hofmann, F ^{[1
]}

Holzapfl, B ^{[1
]}

Schindler-Bauer, P ^{[1
]}

Thewes, R ^{[1
]}

机构：

[1] Infineon Technol AG, Corp Rest, D-81730 Munich, Germany

来源：

IEEE JOURNAL OF SOLID-STATE CIRCUITS | 2004年 / 39卷 / 12期

关键词：

DNA; electrochemical devices; chemical transducers; CMOS integrated circuits; current measurement; drugs; microelectrodes;

D O I：

10.1109/JSSC.2004.837084

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

A 16 x 8 sensor array chip for fully electronic DNA detection is presented. The sensor principle is based on an electrochemical redox cycling process. The chip is fabricated on the basis of an extended 0.5 mum CMOS process. Each sensor site of the array chip contains a complete A/D converter with a dynamic range of five decades. The 3sigma-homogeneity of the electrical response of the sensor array is better than 6% (10(-11) A to 10(-7) A) and better than 20% (10(-12) A to 10(-7) A). Proper operation of the chip is demonstrated with electrochemical and biological experiments.

引用

页码：2438 / 2445

页数：8

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