Ligand-Accelerated Gold-Catalyzed Addition of in Situ Generated Hydrazoic Acid to Alkynes under Neat Conditions

被引：45

作者：

Li, Xiaoqing ^{[1
,2
]}

Liao, Shengrong ^{[1
]}

Wang, Zhixun ^{[1
]}

Zhang, Liming ^{[1
]}

机构：

[1] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA

[2] Zhejiang Univ Technol, Dept Chem Engn, Hangzhou 310014, Zhejiang, Peoples R China

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 14期

关键词：

C BOND-CLEAVAGE; VINYL AZIDES; ORGANIC AZIDES; NITROGENATION; HYDROAZIDATION;

D O I：

10.1021/acs.orglett.7b01359

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The direct addition of in situ generated hydrazoic acid to alkynes is realized without solvent by using a gold catalyst derived from a recently designed remotely functionalized biaryl-2-ylphosphine ligand (i.e., WangPhos). With terminal alkynes, the additions are mostly realized with 0.1 mol% catalyst loadings and at 40 degrees C. With more challenging internal alkynes devoid of direct EWG substitution, the one-step transformation is realized for the first time, with generally high efficiency at ambient temperature.

引用

页码：3687 / 3690

页数：4

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