A light-modulated sequence-specific DNA-binding peptide

被引：0
|
作者：
Caamaño, AM
Vázquez, ME
Martínez-Costas, J
Castedo, L
Mascareñas, JL [1 ]
机构：
[1] Univ Santiago de Compostela, Dept Quim Organ, Santiago De Compostela 15706, Spain
[2] Univ Santiago de Compostela, Unidad Asociada CSIC, Santiago De Compostela 15706, Spain
[3] Univ Santiago de Compostela, Dept Bioquim & Biol Mol, Santiago De Compostela 15706, Spain
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2000年 / 39卷 / 17期
关键词：
D O I：
10.1002/1521-3773(20000901)39:17<3104::AID-ANIE3104>3.0.CO;2-0
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Gripping compounds! A homodimer is formed by linking two monomers of b-ZIP protein basic regions through a photoresponsive azobenzene unit. By simple irradiation at appropriate wavelenghths, this dimer can be switched between isomers which have moderate (trans) and high (cis) sequence-specific affinity for gripping the major groove of DNA (see scheme). BR = basic region, ds = double-stranded.
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页码：3104 / 3107
页数：4
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