iPath3.0: interactive pathways explorer v3

被引：174

作者：

Darzi, Youssef ^{[1
]}

Letunic, Ivica ^{[2
]}

Bork, Peer ^{[3
,4
,5
,6
,7
]}

Yamada, Takuji ^{[1
]}

机构：

[1] Tokyo Inst Technol, Dept Biol Informat, Tokyo 1528550, Japan

[2] Biobyte Solut GmbH, Bothestr 142, D-69126 Heidelberg, Germany

[3] European Mol Biol Lab, Meyerhofstr 1, D-69117 Heidelberg, Germany

[4] Heidelberg Univ, Mol Med Partnership Unit, D-69120 Heidelberg, Germany

[5] European Mol Biol Lab, D-69120 Heidelberg, Germany

[6] Max Delbruck Ctr Mol Med Helmholtz Assoc, D-13125 Berlin, Germany

[7] Univ Wurzburg, Dept Bioinformat, Bioctr, D-97074 Wurzburg, Germany

来源：

NUCLEIC ACIDS RESEARCH | 2018年 / 46卷 / W1期

基金：

欧洲研究理事会; 欧盟地平线“2020”; 日本科学技术振兴机构;

关键词：

D O I：

10.1093/nar/gky299

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

iPath3.0 (http://pathways.embl.de) is a web-application for the visualization and analysis of cellular pathways. It is freely available and open to everyone. Currently it is based on four KEGG global maps, which summarize up to 158 traditional KEGG pathway maps, 192 KEGG modules and other metabolic elements into one connected and manually curated metabolic network. Users can fully customize these networks and interactively explore them through its redesigned, fast and lightweight interface, which highlights general metabolic trends in multi-omics data. It also offers navigation at various levels of details to help users further investigate those trends and ultimately uncover novel biological insights. Support for multiple experimental conditions and time-series datasets, tools for generation of customization data, programmatic access, and a free user accounts system were introduced in this version to further streamline its workflow.

引用

页码：W510 / W513

页数：4

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