Solution-phase parallel synthesis of 4,6-diaryl-pyrimidine-2-ylamines and 2-amino-5,5-disubstituted-3,5-dihydro-imidazol-4-ones via a rearrangement

被引：62

作者：

Varga, L ^{[1
]}

Nagy, T ^{[1
]}

Kövesdi, I ^{[1
]}

Benet-Buchholz, J ^{[1
]}

Dormán, G ^{[1
]}

Ürge, L ^{[1
]}

Darvas, F ^{[1
]}

机构：

[1] ComGenex Inc, H-1388 Budapest 62, Hungary

来源：

TETRAHEDRON | 2003年 / 59卷 / 05期

关键词：

chalcon; 2-amino-pyrimidine; 2-amino-5-benzyl-5-phenyl-3,5-dihydro-imidazol-4-one;

D O I：

10.1016/S0040-4020(02)01560-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of chalcones and guanidine was investigated in the presence of an oxidizing agent. Depending on the order of the addition either a 4,6-diaryl-pyriniidine-2-ylamine or 2-aniino-5,5-disubstituted-3,5-dihydro-imidazol-4-one was obtained. The structures of the imidazolinones were elucidated by NMR spectroscopy and X-ray crystallography and for its formation a mechanism was proposed. (C) 2003 Published by Elsevier Science Ltd.

引用

页码：655 / 662

页数：8

共 17 条

[1] REACTION OF ALPHA,BETA-UNSATURATED KETONES WITH GUANIDINE - SUBSTITUENT EFFECTS ON THE PROTONATION CONSTANTS OF 2-AMINO-4,6-DIARYLPYRIMIDINES [J].